Results 91 to 100 of about 137,716 (306)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Accessibility as a criterion of quality in an architectural spatial environment (on the example of the city of Almaty)

, 2020
The main function of architecture is to arrange living space for everyone regardless of their citizenship, social status, age, and physical abilities.
Gulnara Abdrassilova, Abdrassilova, Gulnara, Elvira Murzagaliyeva, Murzagaliyeva, Elvira   +3 more
core   +1 more source

Mapping Service Accessibility Through Urban Analytics: A Linked Open Data Approach in the Lazio Region (Italy)

Smart Cities
This article presents a modular and replicable framework to assess spatial accessibility to essential public services in the Lazio Region (Italy). Current policies, framed within the EU Urban Agenda and the UN Sustainable Development Goals, emphasize ...
Kevin Gumina, Javier García Guzmán, Eva Barrio Reyes, Ana Chacón Tanarro   +3 more
doaj   +1 more source

Analyzing the Accessibility to Primary Health Care Centers Using Geographic Information Systems: A Case Study of Tangier [PDF]

E3S Web of Conferences
Primary Health Care (PHC) is a pillar of any health care system, significantly enhancing population health through improved access and quality of care. This study utilizes Geographic Information System (GIS) tools to examine the spatial accessibility of ...
Bahmane Soukaina, Azyat Abdelilah, Ben Achhab Nizar, Chahboun Assad   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An Application of the Grid-Based Two-Step Floating Catchment Area Method to Assess the Spatial Accessibility of Green Spaces in Seoul, South Korea

ISPRS International Journal of Geo-Information
The conventional Two-Step Floating Catchment Area (2SFCA) method treats large-scale facilities as single centroids, leading to systematic under- and overestimation of spatial accessibility measures.
Jin Shin, Jinwoo Park
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Spatial accessibility analysis of vaccination units in Gansu Province, China (2025)

Human Vaccines & Immunotherapeutics
This study evaluated the spatial accessibility of vaccination units in Gansu Province, China, using the Two-Step Floating Catchment Area (2SFCA) method, with data collected as of December 2025. A total of 2,119 vaccination units registered as of December
Xuefeng Liang, Na Jin, Shuyu Liu, Bingling Zhang, Jing An, Yu Tang, Xuxia Wang   +6 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

High speed/high capacity railway and regional development - evaluation of effects on spatial accessibility [PDF]

In the last decade the theme of high speed infrastructure in Italy has been deeply debated, with different political and technical opinions, which have expanded the time for projects and constructions. As a consequence of this long debate, a redefinition
Badiani, Barbara, Tira, Maurizio, Tiboni, Michela   +2 more
core