Results 71 to 80 of about 137,716 (306)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
The accessibility of spatial channels for stereo and motion
Vision Research, 2006 Using fractal noise images, we measured the dependence of D(min) on the spatial passband (spatial frequency and orientation) over which information was correlated either between the eyes for stereo or between sequential frames for motion. Without affecting the amplitude spectrum of the noise stimulus we used idealized filters to scramble the phase of ...
Hess, Robert F. +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Introducing spatial availability, a singly-constrained measure of competitive accessibility.
, 2022 Accessibility indicators are widely used in transportation, urban and healthcare planning, among many other applications. These measures are weighted sums of reachable opportunities from a given origin, conditional on the cost of movement, and are ...
Christopher D. Higgins +4 more
core +1 more source
Miscellanea Geographica: Regional Studies on Development, 2019 Spatial accessibility is one of fundamental problems of geography, and transport geography in particular. It is one of the key factors affecting the ability to use certain services by the residents of a given area.
Burdziej Jan
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A spatial analysis of residential land prices in Belgium : accessibility, linguistic border and environmental amenities [PDF]
This paper explores the spatial variation of land prices in Belgium. The originality of the methodology is threefold : (1) to work at the spatial extent of an entire country, (2) to compute several accessibility measures to all jobs and several ...
Isabelle Reginster +2 more
core
LandEquitable accessibility to elderly canteens is critical for addressing the challenges of an aging population. Using Nanjing as a case study, this paper constructed an integrated framework that fuses GIS spatial analysis with interpretable machine ...
Xiaoli Wei, Xu Yuan, Yong Xie
doaj +1 more source