Results 51 to 60 of about 137,716 (306)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Open GeosciencesIt is crucial for social sustainability that adolescents have access to social sports services fairly. However, there are few research studies on requirements for sports facilities and spatial accessibility of adolescents at a fine scale.
Cheng Shuang +3 more
doaj +1 more source
Redai diliThe accelerated promotion of new urbanization has brought about population mobility, which has placed greater pressure on megacities in terms of inter-regional competition for high-quality resources in compulsory education and their carrying capacity. To
Wei Ping +3 more
doaj +1 more source
A Random Multiple-Access Protocol with Spatial Interactions [PDF]
Journal of Applied Probability, 2007 We analyse an ALOHA-type random multiple-access protocol where users have local interactions. We show that the fluid model of the system workload satisfies a certain differential equation. We obtain a sufficient condition for the stability of this differential equation and deduce from that a sufficient condition for the stability of the protocol.
Charles Bordenave +2 more
openaire +7 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Novel methods for the estimation of cost–distance decay in potential accessibility models
, 2014 In much accessibility research, arbitrary estimates of the distance sensitivity parameters have been used to represent the distance decay parameters in potential accessibility models.
Östh, John, +2 more
core +1 more source
Frontiers in Earth ScienceThe spatial accessibility of emergency shelters, indicating the difficulty of evacuation and rescue, is crucial for disaster mitigation and emergency management.
Ziyue Wang +4 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Spatially mapped single-cell chromatin accessibility [PDF]
Nature Communications, 2019 Abstract High-throughput single-cell epigenomic assays can resolve cell type heterogeneity in complex tissues, however, spatial orientation is lost. Here, we present single-cell combinatorial indexing on Microbiopsies Assigned to Positions for the Assay for Transposase Accessible Chromatin, or sciMAP-ATAC, as a method for highly ...
Casey A. Thornton +12 more
openaire +4 more sources