Results 61 to 70 of about 2,789,688 (309)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
MODELING SPATIAL ACCESSIBILITY WITHIN DISCRETE CHOICE FRAMEWORK [PDF]
Spatial accessibility is concerned with the opportunity that an individual at a given location possesses to participate in a particular activity or set of activities.
Ulimwengu, John M., Guo, Xiaoqi
core
LandEquitable accessibility to elderly canteens is critical for addressing the challenges of an aging population. Using Nanjing as a case study, this paper constructed an integrated framework that fuses GIS spatial analysis with interpretable machine ...
Xiaoli Wei, Xu Yuan, Yong Xie
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Accessibility as a criterion of quality in an architectural spatial environment (on the example of the city of Almaty) [PDF]
, 2020 The main function of architecture is to arrange living space for everyone regardless of their citizenship, social status, age, and physical abilities.
Gulnara Abdrassilova +3 more
core +1 more source
LandAccess to schools is crucial in determining an area’s functioning and development, especially regarding housing development. This article presents an analysis of the spatial accessibility of educational services in the city.
Konrad Podawca +2 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A spatial analysis of residential land prices in Belgium : accessibility, linguistic border and environmental amenities [PDF]
This paper explores the spatial variation of land prices in Belgium. The originality of the methodology is threefold : (1) to work at the spatial extent of an entire country, (2) to compute several accessibility measures to all jobs and several ...
Isabelle Reginster +2 more
core