Results 131 to 140 of about 2,789,688 (309)

Location, Regional Accessibility and Price Effects: Evidence from Twin Cities Home Sales [PDF]

Regional location factors, with measures of regional accessibility foremost among them, exert a strong influence on urban property markets. While accessibility represents an important regional-scale factor, more local influences such as proximity to ...
Michael Iacono, David Levinson
core  

The tyranny of distance – mapping accessibility to polysomnography services across Australia [PDF]

, 2015
This paper finds that remote and very remote communities continue to experience inequity in health care in accessibility to specialist services such as diagnostic sleep studies.
Cindy Woods
core  

Multi-Scale Network Analysis of Community-Based Senior Centers: Exploring the Intersection of Spatial Embeddedness and Accessibility in Nanjing, China

Buildings
As critical infrastructure of age-friendly cities, senior centers are designed to be embedded in communities and facilitate service accessibility for older adults.
Zhixin Xu, Xiaoming Li
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Relationships between ramp metering and sprawl [PDF]

This paper explores impacts of ramp metering on urban land use. A regression-based transportation model is developed to capture changes in accessibility caused by ramp metering on a highway network. A Land Use Change Indicator (LUCI) model is modified to
Lei Zhang, David Levinson
core  

How do low-carbon city policies shape older adults health? Evidence from environmental and mobility pathways in China

Frontiers in Public Health
ObjectivesAs environmental pollution and population aging become increasingly severe, it is especially important to assess the health co-benefits of climate-related urban policies.
Xiaonan Yue, Yudi Li
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Healthcare accessibility to rabies post-exposure prophylaxis in rural Kenya: implications for vaccine placement and travel time

Frontiers in Microbiology
BackgroundRabid animal bites are a medical emergency, requiring immediate post-exposure prophylaxis (PEP) to prevent human deaths. This study modeled geographical accessibility to health facilities stocking rabies vaccines and assessed the impact of ...
Mumbua Mutunga, Mumbua Mutunga, Mutono Nyamai, Mutono Nyamai, Mutono Nyamai, Stella Mazeri, Daniel Ksee, Marybeth Maritim, Chuchu Mbaire, Chuchu Mbaire, Katie Hampson, S. M. Thumbi, S. M. Thumbi, S. M. Thumbi, S. M. Thumbi   +14 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Place Rank: Valuing Spatial Interactions [PDF]

Accessibility measures the potential of opportunities for interaction. This paper proposes and explores a new flow-based measure, 'place rank' using origin-destination information.
Ahmed El-Geneidy, David Levinson
core