Results 111 to 120 of about 1,688,232 (308)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Machine learning algorithms of riverbed change and environments of the Lower Apalachicola River

Discover Applied Sciences
Coastal areas, deltas, and the lower end of large rivers have experienced profound long-term changes, destabilizing the environmental balance over the previous several decades.
Ali R. Alruzuq, Joann Mossa
doaj   +1 more source

Reconstructing Snow-Free Sentinel-2 Satellite Imagery: A Generative Adversarial Network (GAN) Approach

Remote Sensing
Sentinel-2 satellites are one of the major instruments in remote sensing (RS) technology that has revolutionized Earth observation research, as its main goal is to offer high-resolution satellite data for dynamic monitoring of Earth’s surface and climate
Temitope Seun Oluwadare, Dongmei Chen, Olawale Oluwafemi, Masoud Babadi, Mohammad Hossain, Oluwaseun Ibukun   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

STEPNet: A Spatial and Temporal Encoding Pipeline to Handle Temporal Heterogeneity in Climate Modeling Using AI: A Use Case of Sea Ice Forecasting

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Sea ice forecasting remains a challenging topic due to the complexity of understanding its driving forces and modeling its dynamics. This article contributes to the expanding literature by developing a data-driven, artificial intelligence (AI)-based ...
Sizhe Wang, Wenwen Li, Chia-Yu Hsu
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Usability testing for improving interactive geovisualization techniques [PDF]

, 2002
Usability describes a product’s fitness for use according to a set of predefined criteria. Whatever the aim of the product, it should facilitate users’ tasks or enhance their performance by providing appropriate analysis tools.
Tobon, Caroline
core  

Reconstructing Historical Landsat Time Series Using a Transformer-Based Deep Learning Approach: A Case Study in the Canadian Prairies Region

Canadian Journal of Remote Sensing
The Landsat program is crucial for monitoring environmental changes, benefiting from its long record of moderate-spatial-resolution imagery, well-established calibration, and commitment to providing open-access data.
Masoud Babadi Ataabadi, Darren Pouliot, Dongmei Chen, Temitope Seun Oluwadare   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source