Results 91 to 100 of about 1,677,553 (308)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Spatial sample weighted machine learning for multitemporal land cover change modeling with imbalanced datasets

Big Earth Data
Despite the widespread use of machine learning (ML) models for geospatial applications, adaptations to imbalanced multitemporal land cover (LC) datasets remain underexplored.
Alysha van Duynhoven, Suzana Dragićević   +1 more
doaj   +1 more source

Spatial Pattern and Influencing Factor Analysis of Parcel Lockers in London [PDF]

E3S Web of Conferences
When carriers deliver goods to customers, last-mile delivery is one of the supply chain’s most costly and environmentally damaging components [1].
Kang Xinwei
doaj   +1 more source

Decision map for spatial decision making in urban planning

, 2005
In this paper, we introduce the concept of decision map and illustrate the way this new concept can be used effectively to support participation in spatial decision making and in urban planning. First, we start by introducing our spatial decision process
Pusceddu, Clara, Roy, Bernard, Chakhar, Salem, Mousseau, Vincent   +3 more
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

SFSW Field Sampling Photos for Stinchfield Woods

, 2009
Digital photos were taken during one day in 2009 as part of a field sampling campaign in Stinchfield Woods. At each plot a photo was taken facing north, east, south, west, and up.
University of Michigan, Environmental Spatial Analysis Lab, Gamberg, Peter   +1 more
core  

Spatial analysis of dead pixels [PDF]

, 2014
Considering a rectangular panel of pixels arranged in a grid, we introduce a taxonomy of damages based on spatial arrangements of dysfunctional pixels. We detect these different types of damage in experimental data obtained from a detector from an X-ray ...
Thornby, John Albert, Brettschneider, Julia, Kendall, W. S., Nichols, Thomas E.   +3 more
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Wavelet analysis of spatial coherent structures in the photosphere

, 1999
In this work we present some applications of wavelet analysis to the dynamics of the photosphere as obtained from a good serie of high spatial resolution white light images taken at the Vacuum Tower Telescope (VTT) at the NSO/SPO in October 1996. The use
Berrilli, F, Bruno, R, Bavassano, B., PIETROPAOLO, Ermanno, Straus, T, Cauzzi, G, Smaldone, LA, Consolini, G   +7 more
core