Results 81 to 90 of about 1,677,553 (308)

Graph Representation Learning on Street Networks

ISPRS International Journal of Geo-Information
Street networks provide an invaluable source of information about the different temporal and spatial patterns emerging in our cities. These streets are often represented as graphs where intersections are modeled as nodes and streets as edges between them.
Mateo Neira, Roberto Murcio
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Evaluating Spatial Design Techniques for Solving Land-use Allocation Problems [PDF]

, 2005
This study examines the use of spatial optimization techniques for multi-site land-use allocation problems (MLUA). 'Multi-site' refers to the problem of allocating more than one land-use type in an area, which are difficult problems as they involve ...
Herwijnen, M. van, Van Herwijnen, Marjan, Theodor Stewart, Aerts, Jeroen C J H, Janssen, Ron, Stewart, Theodor J., Marjan Van Herwijnen, Ron Janssen, Janssen, R.; id_orcid, Aerts, J.C.J.H., Janssen, R., Jeroen Aerts, van Herwijnen, M., Stewart, T.J.   +13 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Enhancing urban analysis through lacunarity multiscale measurement

, 2005
Urban spatial configurations in most part of the developing countries showparticular urban forms associated with the more informal urban development ofthese areas.
Alves Junior, S, Barros Filho, M
core  

Spatial analysis of BSE cases in the Netherlands [PDF]

, 2008
Background In many of the European countries affected by Bovine Spongiform Encephalopathy (BSE), case clustering patterns have been observed. Most of these patterns have been interpreted in terms of heterogeneities in exposure of cattle to the BSE agent.
Thomas J Hagenaars, Heres Lourens, Dick J Brus, Brus Dick J, Brus, D.J., Hagenaars, T.H.J., Heres, L., Lourens Heres, Hagenaars Thomas J   +8 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Spatial analysis by distance indices

, 1995
1. A new method of quantifying spatial pattern was introduced for two-dimensional mapped data, with an associated index of aggregation and a test for departures from randomness, based on an attractive algorithm in which individuals in the sample move to ...
Perry, J. N.
core   +1 more source