Results 61 to 70 of about 1,677,553 (308)

The Application of WebGIS Tools for Visualizing Coastal Flooding Vulnerability and Planning for Resiliency: The New Jersey Experience

open access: yesISPRS International Journal of Geo-Information, 2014
While sea level rise is a world-wide phenomenon, mitigating its impacts is a local decision-making challenge that is going to require site-specific remedies.
Richard Lathrop   +3 more
doaj   +1 more source

Understanding the Role of Optimized Land Use/Land Cover Components in Mitigating Summertime Intra-Surface Urban Heat Island Effect: A Study on Downtown Shanghai, China

open access: yesEnergies, 2020
In this study, 167 land parcels of downtown Shanghai, China, were used to investigate the relationship between parcel-level land use/land cover (LULC) components and associated summertime intra-surface urban heat island (SUHI) effect, and further analyze
Yan-jun Guo   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Modelling Global Deforestation Using Spherical Geographic Automata Approach

open access: yesISPRS International Journal of Geo-Information, 2023
Deforestation as a land-cover change process is linked to several environmental problems including desertification, biodiversity loss, and ultimately climate change.
Bright Addae, Suzana Dragićević
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Quantifying Retail Agglomeration using Diverse Spatial Data

open access: yesScientific Reports, 2017
Newly available data on the spatial distribution of retail activities in cities makes it possible to build models formalized at the level of the single retailer.
Duccio Piovani   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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