Results 61 to 70 of about 4,349,499 (279)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Quantifying Retail Agglomeration using Diverse Spatial Data
Scientific Reports, 2017 Newly available data on the spatial distribution of retail activities in cities makes it possible to build models formalized at the level of the single retailer.
Duccio Piovani +2 more
doaj +1 more source
, 2009 This article describes attempts that cross-fertilize spatial science and critical geographies and challenge the analytical/quantitative versus critical/qualitative distinction existing across human geography. The article is organized on the basis of criticisms of positivist quantitative geography; it discusses both (early) attempts to articulate the ...
openaire +1 more source
Spatial Patterns of Poverty in Central-Java Province [PDF]
, 2011 overty is one of the key issues in development program of Indonesia government. Poverty can be caused by geographical factors, namely the natural conditions, such as climate, density of forest, etc. Therefore, poverty problem
Sulandari, Winita +2 more
core
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Path, theme and narrative in open plan exhibition settings [PDF]
, 2003 Three arguments are made based on the analysis of science exhibitions. First,sufficiently refined techniques of spatial analysis allow us to model the impact oflayout upon visitors' paths, even in moderately sized open plans which allow almostrandom ...
Conroy-Dalton, R +3 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Environmental Research Letters, 2020 The effect of air temperature on photosynthesis is important for the terrestrial carbon cycle. The optimum air temperature for photosynthesis is one of the major parameters in data-driven and process-based photosynthesis models that estimate the gross ...
Qing Chang +7 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Car dependence in England and Wales: spatial inequalities and implications for a just transition
Frontiers in Sustainable CitiesThis paper explores the nuances of car dependence in England and Wales by identifying four distinct archetypes that span structural and conscious forms. Employing the 2011 England and Wales Census, archetype prevalence is mapped across the study area at ...
Maria Wood +5 more
doaj +1 more source