From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
A short geostatistical study of the three-dimensional spatial structure of fumonisins in stored maize [PDF]
, 2010 The heterogeneous three-dimensional spatial distribution of mycotoxins has proven to be one of the main limitations for the design of effective sampling protocols.
N. Magan +12 more
core +1 more source
A Complete Temporal and Spatial Logic for Distributed Systems
, 2005 In this paper, we introduce a spatial and temporal logic for reasoning about distributed computation. The logic is a combination of an extension of hybrid logic, that allows us to reason about the spatial structure of a computation, and linear temporal logic, which accounts for the temporal aspects. On the pragmatic side, we show the wide applicability
Dirk Pattinson, Bernhard Reus
openaire +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Temporal and spatial distortions in adult amblyopia [PDF]
, 2007 Amblyopia is a developmental disorder of the visual system that leads to reduced vision in one or both eyes. People suffering from amblyopia show different perceptual deficits like reduced contrast sensitivity, reduced or no stereopsis, spatial ...
Bäumer, Claudia
core
Modelling a two-dimensional spatial distribution of mycotoxin concentration in bulk commodities to design effective and efficient sample selection strategies [PDF]
, 2009 Mycotoxins in agricultural commodities are a hazard to human and animal health. Their heterogeneous spatial distribution in bulk storage or transport makes it particularly difficult to design effective and efficient sampling plans.
Origgi, Simona +6 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Research on Spatial-Temporal Variations of Cultivated Land in China Based on GlobeLand30
Frontiers in Environmental Science, 2022 The period from 2010 to 2020 is a period of rapid economic development in China, with the increasing population and the urbanization level reaching 63.89%. Cultivated land plays an extremely important role in China’s food security.
Hui Cheng, Xiaowei Wang, Danling Chen
doaj +1 more source
Temporal and Spatial Distributions of Bisphenol A in Marine and Freshwaters in Turkey
Archives of Environmental Contamination and Toxicology, 2019 Bisphenol A (BPA), a chemical component used in the manufacture of plastics, is commonly introduced to and detected in aquatic environments. This is the first study conducted to understand the distribution of BPA in the marine and freshwaters of Turkey.
Koray Ozhan, Emel Kocaman
openaire +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source