Results 101 to 110 of about 1,389,285 (222)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
A computational approach to the covert and overt deployment of spatial attention [PDF]
, 2008 Popular computational models of visual attention tend to neglect the influence of saccadic eye movements whereas it has been shown that the primates perform on average three of them per seconds and that the neural substrate for the deployment of ...
Alexandre, Frédéric +2 more
core +2 more sources
Multi-scale 3D Convolution Network for Video Based Person Re-Identification
, 2018 This paper proposes a two-stream convolution network to extract spatial and temporal cues for video based person Re-Identification (ReID). A temporal stream in this network is constructed by inserting several Multi-scale 3D (M3D) convolution layers into ...
Huang, Tiejun +2 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Lighting Direction and Visual Field Modulate Perceived Intensity of Illumination
Frontiers in Psychology, 2013 When interpreting object shape from shading the visual system exhibits a strong bias that illumination comes from above and slightly from the left. We asked whether such biases in the perceived direction of illumination might also influence its perceived
Mark E McCourt +2 more
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Frontiers in Psychology, 2014 Attentional biases toward threat (ABTs) have been described in high anxious individuals and in clinical samples whereas they have been rarely reported in non-clinical samples (Bar-Haim et al., 2007; Cisler and Koster, 2010). Three kinds of ABTs have been
Laura eSagliano +4 more
doaj +1 more source
Spatial attention improves performance in spatial resolution tasks
Vision Research, 1999 This study used peripheral precueing to explore the effect of covert transient attention on performance in spatial resolution tasks. Experiments 1 (Landolt-square) and 2 ('broken-line') measured gap resolution and Experiment 3 measured vernier resolution. In all three tasks the target was presented alone in a large number of possible locations, ranging
Y, Yeshurun, M, Carrasco
openaire +2 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
rTMS over bilateral inferior parietal cortex induces decrement of spatial sustained attention
Frontiers in Human Neuroscience, 2013 Sustained attention is an essential brain function that enables a subject to maintain attention level over the time of a task. In previous work, the right inferior parietal lobe (IPL) has been reported as one of the main brain regions related to ...
Jeyeon eLee +12 more
doaj +1 more source