Results 61 to 70 of about 304,521 (259)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Low-complexity optimal MPSK detection for spatial modulation

Tongxin xuebao, 2015
The low-complexity optimal SM detection algorithm for MQAM signal detection had been proposed,but no similar method was found for MPSK signal.The problem of low-complexity detection for MPSK signal was considered in SM systems.Utilizing 2-D vector ...
Hong-zhi MEN, Ming-lu JIN
doaj   +2 more sources

Spatial Complexity of a Predator-Prey Model with Holling-Type Response

Abstract and Applied Analysis, 2014
We focus on a spatially extended Holling-type IV predator-prey model that contains some important factors, such as noise (random fluctuations), external periodic forcing, and diffusion processes.
Lei Zhang, Zhibin Li
doaj   +1 more source

Modelling H5N1 in Bangladesh across spatial scales: Model complexity and zoonotic transmission risk

Epidemics, 2017
Highly pathogenic avian influenza H5N1 remains a persistent public health threat, capable of causing infection in humans with a high mortality rate while simultaneously negatively impacting the livestock industry.
Edward M. Hill, Thomas House, Madhur S. Dhingra, Wantanee Kalpravidh, Subhash Morzaria, Muzaffar G. Osmani, Mat Yamage, Xiangming Xiao, Marius Gilbert, Michael J. Tildesley   +9 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

GEO-MATHEMATICAL MODELLING OF SPATIAL-ECOLOGICAL COMPLEX SYSTEMS: AN EVALUATION

Geography, Environment, Sustainability, 2010
Assessing the complexity of landscapes is one of the top research priorities for Physical Geography and Ecology. This paper aims at a methodological evaluation of the discrete and analytical mathematical models hitherto available for quantitative ...
Fivos Papadimitriou
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Quantifying the Complexity of Rough Surfaces Using Multiscale Entropy: The Critical Role of Binning in Controlling Amplitude Effects

Mathematics
A salient feature of modern material surfaces used in cutting-edge technologies is their structural and spatial complexity, which endows them with novel properties and multifunctionality.
Alex Kondi, Vassilios Constantoudis, Panagiotis Sarkiris, Evangelos Gogolides   +3 more
doaj   +1 more source

Spatial summation for complex bar patterns

Vision Research, 1980
We have obtained contrast detection thresholds for spatial grating patterns of limited coherence length for square target fields subtending 2 × 2′ up to 4 × 4°. The results are consistent with a form of physiological summation in which the spatial numerical energy determines the detectability of the pattern.
Koenderink, J.J., Doorn, A.J. van
openaire   +3 more sources