Results 101 to 110 of about 1,009,749 (294)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Cosmic ray acceleration at supergalactic accretion shocks: a new upper energy limit due to a finite shock extension

open access: yes, 2002
Accretion flows onto supergalactic-scale structures are accompanied with large spatial scale shock waves. These shocks were postulated as possible sources of ultra-high energy cosmic rays.
Bhattacharjee   +10 more
core   +1 more source

Analysis of the Spatial Configuration in Cinema on a Human Scale: ‘The Secret World of Arrietty’

open access: yesEtkileşim
Space design is a research field with a broad framework that interacts with different disciplines. Scale, one of the most important components of this field, is used to increase the cinematic effect in the configuration of f ilm spaces.
Zeynep Fatma Niğdeli   +1 more
doaj   +1 more source

Reorganization of spatial configurations in visual working memory: A matter of set size?

open access: yesPLoS ONE, 2019
Humans process single objects in relation to other simultaneously maintained objects in visual working memory. This interdependence is called spatial configuration.
J David Timm, Frank Papenmeier
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Proximity Sensor for Measuring Social Interaction in a School Environment

open access: yesSensors
Social interactions are characterized by being very diverse and changing over time. Understanding this diversity and dynamics, as well as their emerging patterns, is of great interest from social, health, and educational perspectives.
Tania Karina Hernández-Heredia   +4 more
doaj   +1 more source

The spatial configuration of local climate zones reveals effects on wayfinding in human walking. [PDF]

open access: yesPLoS One, 2023
Fan PY   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Seeing visual word forms: Spatial summation, eccentricity and spatial configuration

open access: yesVision Research, 2012
We investigated observers' performance in detecting and discriminating visual word forms as a function of target size and retinal eccentricity. The contrast threshold of visual words was measured with a spatial two-alternative forced-choice paradigm and a PSI adaptive method. The observers were to indicate which of two sides contained a stimulus in the
Kao, Chien-Hui, Chen, Chien-Chung
openaire   +2 more sources

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

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