Results 101 to 110 of about 202,726 (265)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Proximity Sensor for Measuring Social Interaction in a School Environment

Sensors
Social interactions are characterized by being very diverse and changing over time. Understanding this diversity and dynamics, as well as their emerging patterns, is of great interest from social, health, and educational perspectives.
Tania Karina Hernández-Heredia, Cesar Fabián Reyes-Manzano, Diego Alonso Flores-Hernández, Gabriel Ramos-Fernández, Lev Guzmán-Vargas   +4 more
doaj   +1 more source

Effect of soil spatial configuration on Trifolium repens varies with resource amount. [PDF]

PLoS One, 2022
Pan YW, Ying ZX, Nobis MP, Hersperger AM, Shi C, Ge G.   +5 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial configuration of charge and hydrophobicity tune particle transport through mucus. [PDF]

Biophys J, 2022
Samad T, Witten J, Grodzinsky AJ, Ribbeck K.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Spatial Configuration and Force Analyses of Hoses in a Fully Hose-Based Conveyance System

Journal of Marine Science and Engineering
The conveying hose is an important piece of equipment in the field of Marine engineering. Its spatial configuration and force conditions affect the normal operation of the Marine engineering system.
Jun Li, Kai Zhan, Ming Zhang, Yangrui Cheng, Yingying Wang   +4 more
doaj   +1 more source

Surface lattice engineering for fine-tuned spatial configuration of nanocrystals. [PDF]

Nat Commun, 2021
Jiang B, Yuan Y, Wang W, He K, Zou C, Chen W, Yang Y, Wang S, Yurkiv V, Lu J.   +9 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Evaluating changes in spatial configuration in Makassar: A space syntax approach

European Spatial Research and Policy
As cities expand, their morphology and spatial configuration evolve, necessitating the integration of new spatial plans with existing ones to preserve urban identity. Understanding these changes is crucial for sustainable urban development and effective
Andi Andre Pratama Putra
doaj   +1 more source