Results 91 to 100 of about 226,967 (265)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Mutation or Reusing: A Decision Based on Functional Analysis of Historical Houses’ Configurations

Buildings
The present study aims to explore the relationship between theory and practice by evaluating the feasibility of quantification and evaluation for assessing the spatial performance and circulation logic in historic domestic architecture to inform adaptive
Wafaa Anwar Sulaiman Goriel, Tamás Molnár, Erzsébet Szeréna Zoltán   +2 more
doaj   +1 more source

Editorial: Chromatin Spatial Configuration and Function in Metazoans. [PDF]

Front Genet, 2021
Delgado-Olguín P, Oktaba K, Furlan-Magaril M.   +2 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Assessment of the architectural characteristics of student hostels and students’ well-being in higher education

Frontiers in Built Environment
The environment where students’ live highly influence their physical, mental, and social well-being, yet limited evidence exists on how hostel architecture affects well-being in Nigerian universities, where growing enrolment and weak maintenance culture ...
Aniefon Essien, Ebere Donatus Okonta, Eghosa Ekhaese, Daniel Babalola, Excel Michael   +4 more
doaj   +1 more source

Effect of soil spatial configuration on Trifolium repens varies with resource amount. [PDF]

PLoS One, 2022
Pan YW, Ying ZX, Nobis MP, Hersperger AM, Shi C, Ge G.   +5 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Mekân Dizimi: Mekânsal Örgütlenmeyi Grafikleştirme, Sayısallaştırma, Okuma ve Yorumlama

PLANARCH - Design and Planning Research
Mekân dizimi, mekânsal örgütlenmeler arasındaki benzerlik ya da farklılıkları analiz etmek için kullanılan bir yöntemdir. Bu çalışma, bu yöntemin kullanımına ilişkin detayları bir uygulama üzerinden ortaya çıkarmayı amaçlamaktadır.
Ayhan Bekleyen
doaj   +1 more source

Spatial configuration of charge and hydrophobicity tune particle transport through mucus. [PDF]

Biophys J, 2022
Samad T, Witten J, Grodzinsky AJ, Ribbeck K.   +3 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source