Results 71 to 80 of about 202,726 (265)
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
THE TOPOLOGY OF SUBSPACES OF THE CONFIGURATION SPACE OF SPATIAL PENTAGONS
JP Journal of Geometry and Topology, 2023 We assume that four bond angles of a spatial hexagon are . According to the choice of the four bond angles, we define the configuration spaces , and . We determine the topological types of these spaces.
openaire +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Nano ResearchThe shortage of anion exchange membranes (AEMs) with both high hydroxide conductivity and stable physicochemical properties remains a major impediment to the development of high-performance AEM water electrolysis (AEMWE) technology. Herein, we designed a
Yao Li +14 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Spatial Configuration and Emergency Department Performance: A Review of Space Syntax Applications
BuildingsEmergency departments (EDs) operate under high-pressure and time-critical conditions in which spatial configuration plays a fundamental role in shaping workflow efficiency, staff coordination, and patient experience.
Monirh Aldagany +2 more
doaj +1 more source
The Spatial Configuration of the Firm and the Management of Sunk Costs*
Economic Geography, 1997 Abstract:In this paper we explain why the modern corporation may persist with a decentralized system of plants differentiated by the vintage of capital and the style of management. Our goal is to show how and why firms are, at once, structured by the inherited configuration of capital and also reproduce differentiation within and outside the ...
Clark, G, Wrigley, N
openaire +3 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source