Results 61 to 70 of about 226,967 (265)

A VR–SEM Framework for Pre-Occupancy Evaluation of Classroom Spatial Experience

open access: yesBuildings
Architectural design decisions in educational buildings often rely on spatial parameters such as ceiling height and window layout, yet systematic methods for evaluating their influence on user experience during early design stages remain limited.
Yuanzhao Liu   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Effects of Ultrasonic Treatment on the Structure and Antioxidant Activity of Conjugates Formed by Porcine Blood Meal-Derived Peptides and Hemin

open access: yesFoods
Porcine blood meal-derived hydrolysate peptides and hemin are natural antioxidants, and the formation of peptide–hemin conjugates can synergistically improve antioxidant performance.
Juanjuan Du   +6 more
doaj   +1 more source

The Spatial Configuration of the Firm and the Management of Sunk Costs*

open access: yesEconomic Geography, 1997
Abstract:In this paper we explain why the modern corporation may persist with a decentralized system of plants differentiated by the vintage of capital and the style of management. Our goal is to show how and why firms are, at once, structured by the inherited configuration of capital and also reproduce differentiation within and outside the ...
Clark, G, Wrigley, N
openaire   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The impact of spatial configuration on residential communal places Erbil residential complexes as a case study.

open access: yesSulaimani Journal for Engineering Sciences
In modern residential complexes, place quality arises from residents' subjective experiences and objective spatial arrangements. Movement potential and illuminated visibility influence daily use, safety, and environmental legibility.
Mashkhal Khalid Abdullah   +1 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

open access: yesFEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui   +4 more
wiley   +1 more source

Spatial Configuration and Cultural Logic: A Space Syntax Analysis of Wu Family Manor, a Late Qing Merchant’s Garden Residence in Northern China

open access: yesBuildings
Traditional Chinese gardens are not only aesthetic representations but also spatial expressions of diverse aspects of social life. Compared with the extensive studies on Jiangnan gardens, the spatial organization and cultural meanings of private gardens ...
Xinguo Zhang   +4 more
doaj   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Wayfinding in historical urban landscapes: unraveling the spatial-behavioral dynamics in Eskisehir’s Odunpazari

open access: yesJournal of Asian Architecture and Building Engineering
This study explores the interplay between route planning and wayfinding in Eskisehir Odunpazari’s historical landscape, focusing on the influence of spatial configuration and familiarity on navigation strategies.
Elif Celik, Ozge Ceylin Yildirim
doaj   +1 more source

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