Results 111 to 120 of about 202,726 (265)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

The Spatial Logic of Privacy: Uncovering Privacy Patterns in Shared Housing Environments

open access: yesBuildings
In response to the growing relevance of shared housing models such as co-living and co-housing, this study investigates how spatial configuration affects the experience and negotiation of privacy in shared domestic environments.
Ana Moreira, Francisco Serdoura
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Climate-Responsive Design for Sustainable Housing: Thermal Comfort, Spatial Configuration, and Environmental Satisfaction in Subtropical Void Decks

open access: yesBuildings
With rapid urbanization and intensifying climate change impacts, the thermal comfort performance of semi-outdoor spaces has emerged as a critical issue in sustainable urban design and housing development.
Shan Chen, Jinbo Feng, Fei Xue, Qiong Hu
doaj   +1 more source

Soft Office: a human-robot collaborative system for adaptive spatial configuration. [PDF]

open access: yesConstr Robot, 2021
Yablonina M   +3 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Empirical Assessment of Audience Attraction in Shopping Centres Based on the Notion of Social Sustainability

open access: yesTehnički Glasnik
This study addresses the contemporary focus of commercial spaces on enhancing social, cultural, and economic experiences to attract individuals, prompting architects to align designs with audience objectives. It explores social sustainability dimensions,
Reza Askarizad   +2 more
doaj   +1 more source

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