Results 91 to 100 of about 2,181,625 (282)

Correlation Filters With Adaptive Multiple Contexts for Visual Tracking

open access: yesIEEE Access, 2020
The local contexts define the target and its surrounding background within a constrained region, and have been proved useful for visual tracking, but how to adaptively employ them for building robust models remains challenging.
Feng Li, Hongzhi Zhang, Shan Liu
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Geospatial data integration with Semantic Web services: the eMerges approach [PDF]

open access: yes, 2007
Geographic space still lacks the semantics allowing a unified view of spatial data. Indeed, as a unique but all encompassing domain, it presents specificities that geospatial applications are still unable to handle.
Davies, Rob   +7 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

A multi-dimensional framework for improving data reliability in mobile crowd sensing

open access: yesEgyptian Informatics Journal
Mobile Crowd Sensing (MCS) has become a promising new data perception paradigm. It is to be able to easily submit the wrong or untrusted data for the malicious attackers in such an environment.
Xu Wu, Yanjun Song, Junyu Lai
doaj   +1 more source

Spatial effects and Verdoorn law in the Portuguese context [PDF]

open access: yes
The consideration of spatial effects at a regional level is becoming increasingly frequent and the work of Anselin (1988), among others, has contributed to this.
Martinho, Vítor João Pereira Domingues
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Entrepreneurship, Development, and the Spatial Context Retrospect and Prospect [PDF]

open access: yes
Entrepreneurship has been a topical issue in the business administration literature, but in the past decade a wave of interest can be observed on the role of entrepreneurship in the economic growth literature.
Nijkamp, Peter
core  

Epistemologies of Spaces and Places: An Introduction [PDF]

open access: yes, 2014
The article introduces a special themed issue of Theory of Science on epistemologies of spaces and places. It provides a disciplinary context of the theme and reviews some of the key arguments that led to the so-called spatial turn in social sciences and
Hladík, Radim
core  

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