Results 81 to 90 of about 4,357,372 (295)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Building information modelling for 3D underground land administration: Research challenges and future pathways

Underground Space
Underground land and property information is currently recorded, registered, and managed using two-dimensional (2D) datasets provided in survey plans. There are significant communication challenges associated with fragmented 2D land and property data in ...
Lanxuan Shen, Behnam Atazadeh, Serene Ho, Abbas Rajabifard   +3 more
doaj   +1 more source

Forecasting with Spatial Panel Data [PDF]

This paper compares various forecasts using panel data with spatial error correlation. The true data generating process is assumed to be a simple error component regression model with spatial remainder disturbances of the autoregressive or moving average
Baltagi, Badi H., Bresson, Georges, Pirotte, Alain   +2 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Viewpoint Selection for 3D Scenes in Map Narratives

ISPRS International Journal of Geo-Information
Narrative mapping, an advanced geographic information visualization technology, presents spatial information episodically, enhancing readers’ spatial understanding and event cognition. However, during 3D scene construction, viewpoint selection is heavily
Shichuan Liu, Yong Wang, Qing Tang, Yaoyao Han   +3 more
doaj   +1 more source

Querying 3D Cadastral Information from BIM Models

ISPRS International Journal of Geo-Information, 2019
There has been significant research on the intersection of 3D cadastre and building information modelling (BIM) over the recent years. BIM provides a multidimensional environment for capturing, curating and communicating the physical and functional ...
Behnam Atazadeh, Abbas Rajabifard, Yibo Zhang, Maryam Barzegar   +3 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Spatial data

, 2009
Countries that have sustainable development and application of the principles of good governancee in perspective, sooner or later start developing strategies for development and implementation of National spatial data infrastructure (NSDI). In the Republic of Macedonia (RM) the needd for development of NSDI should be accepted and observed from ...
openaire   +3 more sources

Personalized region of interest recommendation through adaptive fusion of multi-dimensional user preferences

Journal of Big Data
Region of interest (ROI) recommendation is essential for delivering personalized suggestions and optimizing resource allocation. This process involves analyzing users’ historical check-in data within location networks, which helps capture spatial ...
Qing Tang, Shenghua Xu, Zhuolu Wang, Yong Wang, Shichuan Liu, Haiqin Hua   +5 more
doaj   +1 more source