Results 81 to 90 of about 4,369,639 (344)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Building information modelling for 3D underground land administration: Research challenges and future pathways

open access: yesUnderground Space
Underground land and property information is currently recorded, registered, and managed using two-dimensional (2D) datasets provided in survey plans. There are significant communication challenges associated with fragmented 2D land and property data in ...
Lanxuan Shen   +3 more
doaj   +1 more source

Spatial Random Sampling: A Structure-Preserving Data Sketching Tool

open access: yes, 2017
Random column sampling is not guaranteed to yield data sketches that preserve the underlying structures of the data and may not sample sufficiently from less-populated data clusters.
Atia, George, Rahmani, Mostafa
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Forecasting with Spatial Panel Data [PDF]

open access: yes
This paper compares various forecasts using panel data with spatial error correlation. The true data generating process is assumed to be a simple error component regression model with spatial remainder disturbances of the autoregressive or moving average
Baltagi, Badi H.   +2 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Viewpoint Selection for 3D Scenes in Map Narratives

open access: yesISPRS International Journal of Geo-Information
Narrative mapping, an advanced geographic information visualization technology, presents spatial information episodically, enhancing readers’ spatial understanding and event cognition. However, during 3D scene construction, viewpoint selection is heavily
Shichuan Liu   +3 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Spatial data

open access: yes, 2009
Countries that have sustainable development and application of the principles of good governancee in perspective, sooner or later start developing strategies for development and implementation of National spatial data infrastructure (NSDI). In the Republic of Macedonia (RM) the needd for development of NSDI should be accepted and observed from ...
openaire   +3 more sources

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