Results 71 to 80 of about 3,193,900 (299)
Queries about the largest empty rectangle in large 2-dimensional datasets stored in secondary memory
Ingeniería e Investigación, 2017 Let be a set of points located in a rectangle and is a point that is not in . This article describes the design, implementation, and experimentation of different algorithms to solve the following two problems: (i) Maximum Empty Rectangle (MER), which ...
Felipe Lara +3 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Towards Intelligent Databases [PDF]
, 1993 This article is a presentation of the objectives and techniques of deductive databases. The deductive approach to databases aims at extending with intensional definitions other database paradigms that describe applications extensionaUy.
Bry, François +2 more
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Dynamic tile-map generation for crack-free rendering of large-scale terrain data
ETRI JournalThree-dimensional (3D) geospatial technologies are essential in urban digitaltwins, smart cities, and metaverse. Rendering large-scale terrain data, oftenexceeding tens of terabytes, presents challenges.
Cheonin Oh, Ahyun Lee
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Polynomial Spatial Constraint Databases
, 2015 The framework of constraint databases provides a general model for spatial databases. In the constraint model, a polynomial spatial constraint database contains a finite number of relations, that, although conceptually viewed as possibly infinite sets of
Kuijpers, Bart
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Optimizing Spatial Databases [PDF]
This paper describes the best way to improve the optimization of spatial databases: through spatial indexes. The most commune and utilized spatial indexes are R-tree and Quadtree and they are presented, analyzed and compared in this paper. Also there are
Åžtefan OLARU, Anda VELICANU
core