Results 51 to 60 of about 117,286 (265)
Queries about the largest empty rectangle in large 2-dimensional datasets stored in secondary memory
Ingeniería e Investigación, 2017 Let be a set of points located in a rectangle and is a point that is not in . This article describes the design, implementation, and experimentation of different algorithms to solve the following two problems: (i) Maximum Empty Rectangle (MER), which ...
Felipe Lara +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Dynamic tile-map generation for crack-free rendering of large-scale terrain data
ETRI JournalThree-dimensional (3D) geospatial technologies are essential in urban digitaltwins, smart cities, and metaverse. Rendering large-scale terrain data, oftenexceeding tens of terabytes, presents challenges.
Cheonin Oh, Ahyun Lee
doaj +1 more source
IEEE AccessEnsuring flight safety for unmanned aerial vehicles (UAVs) is a critical concern, necessitating effective mathematical modeling for safety forecasting in both academic and industrial contexts.
Mingbo Pan +6 more
doaj +1 more source
An extensible index for spatial databases [PDF]
Proceedings Thirteenth International Conference on Scientific and Statistical Database Management. SSDBM 2001, 2002 Emerging database applications require the use of new indexing structures beyond B-trees and R-trees. Examples are the k-D tree, the trie, the quadtree, and their variants. They are often proposed as supporting structures in data mining, GIS, and CAD/CAM applications.
Walid G. Aref, Ihab F. Ilyas
openaire +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Gridvoronoi: An Efficient Spatial Index for Nearest Neighbor Query Processing
IEEE Access, 2019 In this paper, based upon Voronoi Diagram, we propose GridVoronoi which is a novel spatial index that enables users to find the spatial nearest neighbour (NN) from two-dimensional (2D) datasets in almost O(1) time.
Chongsheng Zhang +3 more
doaj +1 more source