Results 61 to 70 of about 437,980 (285)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Queries about the largest empty rectangle in large 2-dimensional datasets stored in secondary memory
Ingeniería e Investigación, 2017 Let be a set of points located in a rectangle and is a point that is not in . This article describes the design, implementation, and experimentation of different algorithms to solve the following two problems: (i) Maximum Empty Rectangle (MER), which ...
Felipe Lara +3 more
doaj +1 more source
Monitoring land use changes using geo-information : possibilities, methods and adapted techniques [PDF]
, 2001 Monitoring land use with geographical databases is widely used in decision-making. This report presents the possibilities, methods and adapted techniques using geo-information in monitoring land use changes.
Hazeu, G.W., Zeeuw, C.J., de
core +1 more source
Linear separability in spatial databases [PDF]
Knowledge and Information Systems, 2017 Given two point sets $R$ and $B$ in the plane, with cardinalities $m$ and $n$, respectively, and each set stored in a separate R-tree, we present an algorithm to decide whether $R$ and $B$ are linearly separable. Our algorithm exploits the structure of the R-trees, loading into the main memory only relevant data, and runs in $O(m\log m + n\log n)$ time
Gutiérrez, Gilberto +2 more
openaire +2 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Efficient Computation of the
IEEE AccessProximity searches within metric spaces are critical for numerous real world applications, including pattern recognition, multimedia information retrieval, and spatial data analysis, among others.
Rodrigo Torres-Aviles, Monica Caniupan
doaj +1 more source
Knowledge discovery in spatial databases: the PADRÃO’s qualitative approach [PDF]
, 2000 Knowledge discovery in databases is a complex process concerned with the discovery of relationships and other descriptions from data. Knowledge discovery in spatial databases represents a particular case of discovery, allowing the discovery of ...
Amaral, Luís, Santos, Maribel Yasmina
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source