Results 41 to 50 of about 3,193,900 (299)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Query processing of spatial objects: Complexity versus Redundancy [PDF]
, 1993 The management of complex spatial objects in applications, such as geography and cartography, imposes stringent new requirements on spatial database systems, in particular on efficient query processing. As shown before, the performance of spatial query
Kriegel, Hans-Peter +3 more
core +1 more source
Energies, 2019 The paper presents a holistic and quantitative model of social gamification in a smart city, which is likely to stimulate the photovoltaic panels installation. The coupling of multi-agent systems, GIS tools, demographic data, and a spatial knowledge base
Robert Olszewski +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Spatial models for context-aware indoor navigation systems: A survey [PDF]
, 2012 This paper surveys indoor spatial models developed for research fields ranging from mobile robot mapping, to indoor location-based services (LBS), and most recently to context-aware navigation services applied to indoor environments.
Christophe Claramunt +6 more
core +1 more source
Resource Capacitated Collective Travel Planning in Spatial Databases
IEEE Access, 2020 The widespread use of GPS smart devices has allowed users to collect location information in real-time, leading to the emergence of ride-sharing services based on users' locations. Ride-sharing services have become effective services that reduce the cost
Junkyu Lee, Seog Park
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Using Visualization to Support Data Mining of Large Existing Databases [PDF]
, 1994 In this paper. we present ideas how visualization technology can be used to improve the difficult process of querying very large databases. With our VisDB system, we try to provide visual support not only for the query specification process. but also for
Kriegel, Hans-Peter +3 more
core +1 more source