Results 91 to 100 of about 874,317 (267)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Spatial Inequality and Development [PDF]
, 2005 Abstract Drawing on data from 25 countries from all regions of the world, this book addresses questions that have become very important in recent years, as the spatial dimensions of inequality have begun to attract considerable policy interest; what is spatial inequality? Why does it matter?
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Identifying levers of urban neighbourhood transformation using serious games
npj Urban SustainabilityGrowing urban population and contemporary urban systems lock-in unsustainable urban development pathways, deteriorating the living quality of urban dwellers.
Johann S. Schuur +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
InformationThe valuation of real estate is a fundamental process for the proper functioning of the market and the formulation of public policies. The mother of the traditional methodologies is the comparative method, which is based on data that is often incomplete ...
Nikolaos Karanikolas +2 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingMonitoring the behavior of surge-type glaciers is important for our understanding of glacier dynamics. However, in central East Greenland, one of the two clusters of surge-type glaciers in Greenland, only a few studies recorded the detailed surge ...
Xiaohan Yuan, Zixiang Sun, Gang Qiao
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The European Spatial Development Perspective
European Journal of Spatial Development, 2001 Item does not contain ...
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source