Results 91 to 100 of about 879,955 (267)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Spatial Inequality and Development [PDF]
, 2005 Abstract Drawing on data from 25 countries from all regions of the world, this book addresses questions that have become very important in recent years, as the spatial dimensions of inequality have begun to attract considerable policy interest; what is spatial inequality? Why does it matter?
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
InformationThe valuation of real estate is a fundamental process for the proper functioning of the market and the formulation of public policies. The mother of the traditional methodologies is the comparative method, which is based on data that is often incomplete ...
Nikolaos Karanikolas +2 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingMonitoring the behavior of surge-type glaciers is important for our understanding of glacier dynamics. However, in central East Greenland, one of the two clusters of surge-type glaciers in Greenland, only a few studies recorded the detailed surge ...
Xiaohan Yuan, Zixiang Sun, Gang Qiao
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The European Spatial Development Perspective
European Journal of Spatial Development, 2001 Item does not contain ...
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Identifying levers of urban neighbourhood transformation using serious games
npj Urban SustainabilityGrowing urban population and contemporary urban systems lock-in unsustainable urban development pathways, deteriorating the living quality of urban dwellers.
Johann S. Schuur +3 more
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