Results 71 to 80 of about 874,317 (267)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Valuation of Public Urban Space: From Social Value to Fair Value—Mind the Gap

Land
Urban public spaces function as complex social and spatial systems, serving as fundamental elements in preserving cultural heritage and fostering democratic participation and urban stability.
Nikolaos Karanikolas, Eleni Athanasouli, Eleni Kyriakidou   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Urban streams as focal points of urban regeneration: The area of Konstantinidis stream in Toumba, Thessaloniki [PDF]

E3S Web of Conferences
Nowadays, the concept of Green Infrastructure (GI) is having a big impact when it comes to planning cities and to policymaking, due to the need for substantial rethinking of urban development and for a contemporary way to respond to the current ...
Kastanidou Symela, Katsavounidou Garyfallia   +1 more
doaj   +1 more source

Evidence supportive of a bacterial component in the etiology for Alzheimer's disease and for a temporal-spatial development of a pathogenic microbiome in the brain. [PDF]

Front Cell Infect Microbiol, 2023
Moné Y, Earl JP, Król JE, Ahmed A, Sen B, Ehrlich GD, Lapides JR.   +6 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Integrating climate change adaptation policies in spatial development planning in hyperarid regions of Kerman province, Iran. [PDF]

Heliyon, 2023
Karami H, Sayahnia R, Barghjelveh S.
europepmc   +1 more source

Spatial Development

, 2014
Հետազոտության հիմնական նպատակն է ՀՀ-ում տարածական զարգացման հնարավորությունների գնահատումը և դրանց իրականացման հիմնական ուղղությունների բացահայտումը: Մշակվել են ՀՀ տարածական զարգացման հայեցակարգային հիմնադրույթները: Վերլուծվել են քաղաքների զարգացման բազմաթիվ մոդելներ: Ուսումնասիրվել է տարածական զարգացման միջազգային փորձը և դրա կիրառման ...
Grigoryan, Karen, Atoyan, Koryun, Mkrtchyan, Tatul, Khachikyan, Sos, Terzyan, Tigran, Kolyan, Lilit, Hambartsumyan, Hasmik, Arshakyan, Hakob, Arakelyan, Venera   +8 more
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Thymosin Beta 15 Alters the Spatial Development of Thymic Epithelial Cells. [PDF]

Cells, 2022
Xu X, He K, Hoffman RD, Ying Y, Tao N, Guo W, Shen J, Liu X, Li M, Yan M, Lv G, Gao J.   +11 more
europepmc   +1 more source