Results 31 to 40 of about 3,128,751 (237)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Modelling as a tool for spatial planning of commodity production: the example of certified oil palm plantations in Central Africa [PDF]

, 2014
The Central African region is targeted by agri-business companies as a suitable place to develop large plantations. Most of the existing assessments of available land are based on an a priori definition of availability and without any operational-level ...
Feintrenie, Laurène, Gazull, Laurent, Nkoua, Méthode, Saidi, Slim   +3 more
core  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Spatial Development and Energy Consumption [PDF]

Previous literature has suggested that the urban form (i.e., city size, density, and center distribution pattern) influences urban energy consumption.
Harrington, Winston, Houde, Sébastien, Safirova, Elena A.   +2 more
core  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Economic Debate On Spatial Functional Linkages And Its Application to Key Spatial Development Challanges In Poland [PDF]

This article presents a synthesis of today's world economic knowledge and the results of the analyses concerning: a) the nature of spatial functional linkages, including network structures, b) diversity of approaches concerning the application of spatial
Jacek Zaucha
core  

Spatial Development

, 2014
Հետազոտության հիմնական նպատակն է ՀՀ-ում տարածական զարգացման հնարավորությունների գնահատումը և դրանց իրականացման հիմնական ուղղությունների բացահայտումը: Մշակվել են ՀՀ տարածական զարգացման հայեցակարգային հիմնադրույթները: Վերլուծվել են քաղաքների զարգացման բազմաթիվ մոդելներ: Ուսումնասիրվել է տարածական զարգացման միջազգային փորձը և դրա կիրառման ...
Grigoryan, Karen, Atoyan, Koryun, Mkrtchyan, Tatul, Khachikyan, Sos, Terzyan, Tigran, Kolyan, Lilit, Hambartsumyan, Hasmik, Arshakyan, Hakob, Arakelyan, Venera   +8 more
openaire   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The spatial structure of the financial development in Brazil [PDF]

This paper explores the financial development in Brazil. It focuses on the impacts of the development level of a municipality’s financial system over its neighborhood, under the light of the Central Place Theory. Using a GMM estimator for a spatial panel
Fabiana Santos, Marco Crocco, Pedro Amaral   +2 more
core