Results 41 to 50 of about 933,538 (267)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Indoor air quality in a chemistry laboratory environment [PDF]
Constructii: Journal of Civil Engineering Research, 2017 The indoor built environment is the result of the interaction between the site, climate, building type (original design and later modifications of it), construction techniques, sources of chemical, physical and biological pollutants (building materials ...
Vasilica VASILE, Alina DIMA, Mihaela ION
doaj
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Developments in the Analysis of Spatial Data [PDF]
JOURNAL OF THE JAPAN STATISTICAL SOCIETY, 2008 Disregarding spatial dependence can invalidate methods for analyzing cross-sectional and panel data. We discuss ongoing work on developing methods that allow for, test for, or estimate, spatial dependence. Much of the stress is on nonparametric and semiparametric methods.
openaire +3 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Tourism and Hospitality, 2022 The focus of experiential tourism is for the consumer or visitor to experience the tourist destination and to actively interact with local people, cultures, and the place itself.
Athena Yiannakou +4 more
doaj +1 more source
Actual developments in ICT — Consequences for spatial development and spatial planning
Raumforschung und Raumordnung | Spatial Research and Planning, 2006 Innovation is leading to several new technologies in ICT every year — while mobile phones and the Internet where the leading innovation in the ICT-sector of the 1990s, now the integration of those networks is more important. Due to increasing bandwidths and new wireless technologies more services can be provided by actual data networks.
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source