Results 41 to 50 of about 874,317 (267)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Indoor air quality in a chemistry laboratory environment [PDF]
The indoor built environment is the result of the interaction between the site, climate, building type (original design and later modifications of it), construction techniques, sources of chemical, physical and biological pollutants (building materials ...
Vasilica VASILE, Alina DIMA, Mihaela ION
doaj
The focus of experiential tourism is for the consumer or visitor to experience the tourist destination and to actively interact with local people, cultures, and the place itself.
Athena Yiannakou +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
The gender dimensions of travel time use in Germany
Highlights Men’s solitary ICT use during travel is driven by their economic situation and preference for ICT use. Women’s socializing during travel is primarily influenced by their children and preference for ICT use.
Bhuvanachithra Chidambaram +1 more
doaj +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Biophysical approaches for studying viral entry
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Spatial planning practices of adapting to climate change
Although spatial planning is considered as crucial for climate change adaption, e.g. in the EU White Paper on Adaptation, there are uncertainties regarding the role of adaptation strategies in spatial planning practices. In this paper the potential role
Bart Jan Davidse +2 more
doaj +3 more sources

