Impacts of large scale development: does space make a difference? [PDF]
, 2005 Large scale development, a process to rapidly transform urban built environment since the industrial modernism, has been often criticized for creating fragmented environments that impair urban vitality.
Yang, Tao
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Evidence supportive of a bacterial component in the etiology for Alzheimer's disease and for a temporal-spatial development of a pathogenic microbiome in the brain. [PDF]
Front Cell Infect Microbiol, 2023 Moné Y +6 more
europepmc +1 more source
Commercial Applications Multispectral Sensor System [PDF]
, 1993 NASA's Office of Commercial Programs is funding a multispectral sensor system to be used in the development of remote sensing applications. The Airborne Terrestrial Applications Sensor (ATLAS) is designed to provide versatility in acquiring spectral and ...
Birk, Ronald J., Spiering, Bruce
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Integrating climate change adaptation policies in spatial development planning in hyperarid regions of Kerman province, Iran. [PDF]
Heliyon, 2023 Karami H, Sayahnia R, Barghjelveh S.
europepmc +1 more source
Economization of spatial planning. The case of Poland’s Spatial Development Concept [PDF]
At the regional (subnational) level spatial planning has remained firm mainly in its land use aspects. Despite of pretty advanced legislation in Poland requiring each self-government region to prepare spatial planning outlines based on regional-socio ...
Jacek Zaucha
core
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source