Results 51 to 60 of about 3,560,341 (309)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
International Journal of Digital EarthSanitation facilities are essential human rights that contribute to quality of life and the realization of other rights, as demonstrated by the population coverage of public toilets. Traditional data sources lack spatial information, limiting research on
Junxia Miao +5 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Land, 2022 The concept of Ecosystem Service Value (ESV) is indispensable when balancing the need for economic development and ecological protection, because it can clarify the ecological assets and values provided by a region. The study of spatio-temporal variation
Yi Shang +3 more
doaj +1 more source
Functional differentiation within the monkey cortex as revealed by near-infrared spectroscopy [PDF]
, 2008 The role of prefrontal cortex in working memory (WM) is well established. However, questions remain regarding the topography and “domain-specific differentiation” of different types of information processing in the cortex.
Joaquin M. Fuster +4 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Spatial differentiation and fertility postponement transition in Czechia
Acta Universitatis Carolinae Geographica, 2016 Over the last quarter of a century female fertility in Czechia has undergone dynamic and dramatic change. One of the main indications of this is the postponement of births and associated fertility ageing.
Branislav Šprocha, Luděk Šídlo
doaj +1 more source
ISPRS International Journal of Geo-Information, 2022 Market services industries are closely related to residents’ lives, and its spatial distribution has an important impact on satisfying residents’ consumption needs and promoting economic development.
Jie Chen +5 more
doaj +1 more source
, 2022 Differentiation mechanisms are influenced by the properties of the landscape over which individuals interact, disperse and evolve. Here, we investigate how habitat connectivity and habitat heterogeneity affect phenotypic differentiation by formulating a ...
Boussange, Victor +5 more
core +1 more source