Results 71 to 80 of about 292,395 (311)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

SOCIO-SPATIAL DIFFERENTIATION, SCALE AND SPATIAL PRACTICES

, 2022
O presente texto discute a temática da diferenciação sócio-espacial em algumas de suas relações com a escala conceitual e as práticas espaciais. Resultado inevitável da ação humana, a diferenciação sócio-espacial pode ser concebida segundo
Corrêa, Roberto Lobato
core   +1 more source

Research on Assessing the Spatial Pattern and Driving Factors behind of the Development of County-Level Digital Countryside in China

Redai dili
The 14th Five-Year Plan states the following: "Accelerate the construction of digital countryside, build a comprehensive information service system for agriculture and rural areas, establish an inclusive service mechanism for agriculture-related ...
Liu Chuanming, Wang Rui, Shao Mingji
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

An experimental study on multi-dimensional spatial product differentiation [PDF]

This study presents the results of an experiment on spatial differentiation of products in Hotelling-type models with different grades of complexity for companies’ choices of space.
Przemysław Kusztelak
core  

Research Topics and Changes in the Spatial Structure of Innovativeness of Polish Industry in 2005–2015

Prace Komisji Geografii Przemysłu Polskiego Towarzystwa Geograficznego, 2018
The purpose of the paper was to synthetically characterise the changes of spatial differentiation of industry innovation in Poland in 2005–2015 in the context of research problems of innovativeness with the use of the cross product.
Paweł Brezdeń
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Product Differentiation with Consumer Arbitrage [PDF]

Also published as Working Paper DFAEII 2003-01spatial price discrimination, product differentiation, personal ...
Espinosa Alejos, María Paz, Aguirre Pérez, Iñaki   +1 more
core  

Perspectiva espacial de la migración interna en Cuba en el trienio 2015-2017. Una conducta que no pierde fuerza

Novedades en Población, 2018
Los componentes de cambio de la población han tenido diferencias en cuanto a su magnitud y expresiones territoriales en Cuba. En particular la migración interna ha sido reflejo de los diferentes contextos socioeconómicos del país, por razones que van ...
Wiliam Hernández Mondejar,, Arelis Rosalen Mora Pérez   +1 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source