Results 91 to 100 of about 292,395 (311)

Strategies to boost global food production: Modelling socioeconomic policy scenarios

open access: yesCogent Food & Agriculture, 2017
Current research on food security is dominated by crop, climate and demographic modellers who project how changes in weather and population may affect the global demand and supply of food. But socioeconomic factors also play a crucial role in determining
Krishna Bahadur KC, Evan D.G. Fraser
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Spatial pattern of nerve differentiation in Hydra is due to a pattern of nerve commitment [PDF]

open access: yes, 1981
The pattern of nerve differentiation along the body column of Hydra was investigated. Nerve precursors in late S phase were labeled with [3H]thymidine and their distribution compared with that of newly differentiated nerves.
G. Venugopal   +3 more
core   +1 more source

Dispersal Limitation Dominates Riverine Fish Communities in the Areas of the Water Diversion Project in the Western Sichuan Plateau, China

open access: yesAnimals
The riverine fish species are highly vulnerable and responsive to large-scale water diversion projects. These adverse impacts are more pronounced in the plateau river ecosystems, which may change the environmental conditions of fish habitats and ...
Tao Chang   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Product differentiation in a mixed duopoly [PDF]

open access: yes
This paper analyzes a mixed duopoly with horizontal product differentiation using the unconstrained Hotelling model with quadratic transport costs. Firms play a noncooperative two-stage game on locations (first stage) and prices (second stage), and we ...
Agustín Gil
core  

Analysis of the influence factors of cultivated land transfer in Guangdong coastal important agricultural areas based on geodetectors

open access: yesFrontiers in Sustainable Food Systems
IntroductionsAs a key link in the development of modern agriculture, the transfer of arable land is regarded as a strategic measure to improve agricultural production efficiency and ensure national food security.
Zhaogang Fu, Zhaogang Fu, Qingyi Xue
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

SPATIAL DIFFERENTIATION OF THE EMISSIVITY OF AGRICULTURE IN EUROPE [PDF]

open access: yesAnnals of the Polish Association of Agricultural and Agribusiness Economists
This paper presents the results of a study aimed at determining the spatial variation in the carbon intensity of the agricultural sector in Europe. The analyses used the volume of greenhouse gas emissions from the agricultural sector (in 2020), expressed
Grzegorz Rawa, Robert Pietrzykowski
doaj   +1 more source

Spatial Differentiation and Positive Circuits in a Discrete Framework

open access: yesElectronic Notes in Theoretical Computer Science, 2008
The biologist R. Thomas has enounced a rule relating multistationnarity in a system of genes interacting in a single cell to the existence of a positive circuit in the regulatory graph. In this paper, we address the question of a similar rule for spatial differentiation.
Anne Crumière, Paul Ruet
openaire   +2 more sources

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