Results 101 to 110 of about 292,395 (311)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Equilibrium Nonexistence in Spatial Competition with Quadratic Transportation Costs [PDF]

Under quadratic transportation costs, the existence of the sequential first-locate-thenprice equilibrium in spatial competition is well known in the literature. In this paper, we find that the equilibrium may fail to exist under certain restrictions with
Arguedas, Carmen, Hamoudi, Hamid, Saez, Manuel   +2 more
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A Spatial Signal of Niche Differentiation in Tropical Forests

Explaining diversity in tropical forests remains a challenge in community ecology. Theory tells us that species differences can stabilize communities by reducing competition, while species similarities can promote diversity by reducing fitness ...
D'Andrea, Rafael, Umarani, Mihir S., Wang, Dianzhuo, Wang, Dianzhuo., O'Dwyer, James P.   +4 more
core   +1 more source

Slow Turning Lateral Vessel Bioreactor Improves Embryoid Body Formation and Cardiogenic Differentiation of Mouse Embryonic Stem Cells.

, 2013
Embryonic stem cells (ESCs) have the ability to form aggregates, which are called embryoid bodies (EBs). EBs mimic early embryonic development and are commonly produced for cardiomyogenesis.
Tharasanit, T., Biology of Reproductive Cells, Pirity, M., Rungarunlert, Sasitorn, Klincumhom, Nuttha, Rungarunlert, S., Dinnyés, András, Tharasanit, Theerawat, Dep Gezondheidszorg Landbouwhuisdieren, Klincumhom, N., Techakumphu, M., Pirity, Melinda, Dinnyes, A.   +12 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Price-dependent demand in spatial models [PDF]

This paper introduces price-dependent individual demand into the circular city model of product differentiation. We show that for any finite number of firms, a unique symmetric price equilibrium exists provided that demand functions are not too convex ...
Wenzel, Tobias, Gu, Yiquan
core  

Price Differentiation and Discrimination in Transport Networks [PDF]

, 2014
This paper analyzes the effects of price differentiation and discrimination by a monopolistic transport operator, which sets fares in a congestible network.
van der Weijde, A.H., van der Weijde, Adriaan Hendrik   +1 more
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Study on Spatial Differentiation Characteristics and Driving Mechanism of Sustainable Utilization of Cultivated Land in Tarim River Basin

Land
The sustainable utilization of cultivated land is a crucial prerequisite for ensuring food security and achieving sustainable socioeconomic development.
Yang Sheng, Weizhong Liu, Hailiang Xu
doaj   +1 more source