Results 81 to 90 of about 292,395 (311)

Chapter 5 Product Differentiation versus Geographical Differentiation: Evidence from the Pork Processing Industry in China [PDF]

This chapter attempts to identify whether product differentiation or geographical differentiation is the main source of profit for firms in developing economies by employing a simple idea from the recently developed method of empirical industrial ...
Watanabe, Mariko
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Symmetric and Asymmetric Equilibria in a Spatial Duopoly [PDF]

We describe a spatial duopoly in a Hotelling model with quadratic transportation costs where consumers are distributed according to a symmetric density whose degree of concentration is variable.
Marcella Scrimitore
core  

Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo [PDF]

, 2014
Here, we exploit the spatial separation of temporal events of neural differentiation in the elongating chick body axis to provide the first analysis of transcriptome change in progressively more differentiated neural cell populations in vivo.
Storey, Kate G, Barton, Geoffrey J, Song, Junfang, Storey, Kate G., Halley, Pamela A., Schurch, Nick, Barton, Geoffrey J., Das, Raman M., Li, Roman A, Olivera-Martinez, Isabel, Li, Roman A., Burt, Dave W, Burt, Dave W., Barton, Geoffrey J.; id_orcid, Halley, Pamela A, Li, Roman, Das, Raman M, Das, Raman M; id_orcid   +17 more
core   +1 more source

Spatial differentiation and trade-off /synergy relationship of soil fertility in typical karst peak-cluster depressions

Carsologica Sinica
A scientific evaluation of soil fertility levels in karst peak-cluster depressions at a grid scale is essential for implementing precise fertilization and conservation strategies at the regional level.
Guobin MA, Xingming QIN, Baoqing HU, Zihan QU, Qi SUN   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Unraveling Belowground Community Assembly in Temperate Steppe Ecosystems

Biology
The composition, architecture, and plant traits of temperate steppe communities are intricately associated with environmental factors. However, most studies primarily focus on aboveground observations, often overlooking the critical role of belowground ...
Ping Wang, Shuai Shang, Zhengyang Rong, Jingkuan Sun, Jinzhao Ma, Zhaohua Lu, Fei Wang, Zhanyong Fu   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Analysis of Spatial Distribution and Determinants of Rural Homesteads: A Case Study of Zhaotong, Yunnan

Land
Accurately identifying the spatial differentiation mechanisms of rural homesteads in ecologically fragile mountainous areas is essential for implementing United Nations Sustainable Development Goal 11—building inclusive, safe, resilient, and sustainable ...
Jiangsu Li, Bingqian Sun, Chonglin Chen
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source