Results 111 to 120 of about 3,560,341 (309)

Research on the Spatial Differentiation Characteristics and Influencing Factors of Industrial Heritage

ISPRS International Journal of Geo-Information
Against the background of industrial transformation and urban regeneration in old industrial bases, understanding the spatial pattern and driving mechanisms of industrial heritage is essential for its conservation and sustainable use.
Zexuan Liu, Jiaji Gao, Jun Yang
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Spatial Differentiation Mechanisms and Revitalization Strategies of Traditional Villages in the Xin’an River Basin: A Resilience-Inspired Spatial Planning Approach

Buildings
Traditional villages in ecologically sensitive areas face structural dilemmas between preservation-induced stagnation and excessive commercialization under the combined pressures of rural revitalization and ecological protection.
Fengquan Ji, Ruoqing Zhang, Yuxin Pei
doaj   +1 more source

Chapter 5 Product Differentiation versus Geographical Differentiation: Evidence from the Pork Processing Industry in China [PDF]

This chapter attempts to identify whether product differentiation or geographical differentiation is the main source of profit for firms in developing economies by employing a simple idea from the recently developed method of empirical industrial ...
Watanabe, Mariko
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Spatial Differentiation and Positive Circuits in a Discrete Framework

Electronic Notes in Theoretical Computer Science, 2008
The biologist R. Thomas has enounced a rule relating multistationnarity in a system of genes interacting in a single cell to the existence of a positive circuit in the regulatory graph. In this paper, we address the question of a similar rule for spatial differentiation.
Anne Crumière, Paul Ruet
openaire   +3 more sources

Symmetric and Asymmetric Equilibria in a Spatial Duopoly [PDF]

We describe a spatial duopoly in a Hotelling model with quadratic transportation costs where consumers are distributed according to a symmetric density whose degree of concentration is variable.
Marcella Scrimitore
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Spatial differentiation of the results of the International Geography Olympiad

Miscellanea Geographica: Regional Studies on Development
The aim of the article is to determine the spatial differentiation of iGeo results and to identify its key determinants. Using inferential statistics, we compared contestant success in this competition from 2015 to 2023. The findings indicate significant
Trahorsch Petr, Svobodová Hana
doaj   +1 more source