Results 121 to 130 of about 3,560,341 (309)

GENERIC COMMODITY PROMOTION AND PRODUCT DIFFERENTIATION [PDF]

This paper considers whether generic promotion lowers the differentiation among competing brands as claimed in the 1997 Supreme Court case (Wileman et al. v. Glickman).
Crespi, John M.
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Asymmetric Spatial Competition [PDF]

This paper considers price and location decisions of competing duopolists through an approach that integrates the traditional inside location and outside location model.
Ruby Toh, Sougata Poddar
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Notes on spatial differentiation

, 2022
Resumo Diferenciação espacial é o resultado da ação combinada de processos naturais e sociais que produziu uma superfície terrestre fragmentada, irregular, complexa e mutável, porém articulada. A superfície terrestre pode assim ser vista como um caleidoscópio, possibilitando diferentes leituras.
openaire   +1 more source

A Spatial Signal of Niche Differentiation in Tropical Forests

Explaining diversity in tropical forests remains a challenge in community ecology. Theory tells us that species differences can stabilize communities by reducing competition, while species similarities can promote diversity by reducing fitness ...
D'Andrea, Rafael, Umarani, Mihir S., Wang, Dianzhuo, Wang, Dianzhuo., O'Dwyer, James P.   +4 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Estimation of Residential Vacancy Rate in Underdeveloped Areas of China Based on Baidu Street View Residential Exterior Images: A Case Study of Nanning, Guangxi

Algorithms
Housing vacancy rate is a key indicator for evaluating urban sustainable development. Due to rapid urbanization, population outflow and insufficient industrial support, the housing vacancy problem is particularly prominent in China’s underdeveloped ...
Weijia Zeng, Binglin Liu, Yi Hu, Weijiang Liu, Yuhe Fu, Yiyue Zhang, Weiran Zhang   +6 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The fuzzy boundary: the spatial definition of urban areas [PDF]

, 2007
Cities seem to have some kind of area structure, usually distinguished in terms of land use types, socio-economic variables, physical appearance or historical and culturalcharacteristics.
Hillier, B, Bill Hillier, Yang, T, Tao Yang   +3 more
core