Results 91 to 100 of about 1,155,613 (311)

The spatial distribution of leprosy cases during 15 years of a leprosy control program in Bangladesh: An observational study [PDF]

, 2008
BACKGROUND: An uneven spatial distribution of leprosy can be caused by the influence of geography on the distribution of risk factors over the area, or by population characteristics that are heterogeneously distributed over the area.
Chowdhury, SK, Chowdhury, S. (Susmita), Fischer EAJ, SK Chowdhury, Richardus JH, Pahan, D. (David), EAJ Fischer, Richardus, J.H., Chowdhury, S.K., Fischer, EAJ, Pahan, D, Fischer, E.A.J., pahan, D., Fisher, E. (Eric), Pahan D, Richardus, Jan hendrik; id_orcid, Chowdhury SK, Richardus, J.H. (Jan Hendrik), JH Richardus, D Pahan   +19 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

POPULATION STRUCTURE OF Heteropsis spp. Kunth (TITICA VINE) IN THE TAPAJÓS NATIONAL FOREST, PARÁ-BRAZIL [PDF]

Revista Árvore
The objective of the present study was to analyze the ecological aspects of Heteropsis spp. Kunth (titica vine) in an area maintained under forest management conditions.
Lizandra Elizeário dos Santos, João Ricardo Vasconcellos Gama, Andrea Araújo da Silva, Marcela Gomes da Silva   +3 more
doaj   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Variation in Spatial Predictions Among Species Distribution Modeling Methods [PDF]

Prediction maps produced by species distribution models (SDMs) influence decision-making in resource management or designation of land in conservation planning. Many studies have compared the prediction accuracy of different SDM modeling methods, but few
Alexandra D. Syphard, Janet Franklin
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

EXPLORING SPATIAL CONTAGION IN SPAIN’S INTERNATIONAL MIGRATION DISTRIBUTION [PDF]

This paper explores the Spain’s international migration distribution (SIMD) for the 1998-2009 period. Beyond a general depiction of the distribution, the study pays special attention to the role played by space and, particularly, to the possibility of ...
Maria Hierro
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Using spatial distribution and behaviour to determine optimal space allowances for poultry and rabbits [PDF]

, 2011
Previous research on the effect of stocking density on welfare has focused on adverse effects on health and behaviour. Absence of such effects does not mean that space allowance is optimal from the animals’ point of view.
Buijs, Stephanie
core  

Spatial distribution of human and canine visceral leishmaniasis in Belo Horizonte, Minas Gerais State, Brasil, 1994-1997

Cadernos de Saúde Pública, 2001
In this paper, we present spatial analysis of the association between all incidents cases of human Visceral Leishmaniasis and seropositive dogs, from 1994 to 1997 in Belo Horizonte, a large Brazilian city.
Oliveira Cláudia Di Lorenzo, Assunção Renato Martins, Reis Ilka Afonso, Proietti Fernando Augusto   +3 more
doaj