Results 91 to 100 of about 429,151 (266)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Reseña de libros - Experiencia turística: Perspectivas contemporáneas

PASOS Revista de Turismo y Patrimonio Cultural, 2014
Sharpley, R. & Stone, P. (Eds.) (2011). Tourist experience: Contemporary perspectives. Oxon, UK: Routledge. (ISBN: 978-0-415-57278-1)
Dora Lúcia Agapito
doaj  

Mapping and spatial distribution of relict charcoal hearths across Poland [PDF]

Earth System Science Data
This study presents the first national-scale spatial inventory of relict charcoal hearths (RCHs) in Poland, based on high-resolution LiDAR data and digital terrain analysis.
M. Słowiński, A. Halaś, M. A. Niedzielski, K. Szewczyk, J. Jonczak, D. Łuców, S. Tyszkowski, S. Słowińska, A. Gruszczyńska, B. Kruczkowska, A. Chojnacka, T. Polkowski, K. Sztabkowski, D. Brykała, J. Wolski, T. Samojlik, A. Kaszkiel, B. Gmińska-Nowak, M. Kramkowski, T. Związek   +19 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Exploration of the Urbanization Process and Its Impact on Vegetation in 125 Resource-Based Cities in China and Comparison with Other Cities

Remote Sensing
Resource-based cities (RBCs) in China are at a historic juncture in their transformative development. Observing and assessing the role of the resource curse in urban expansion and greening is crucial for the sustainable development of these cities.
Jiazheng Han, Payam Sajadi, Zhenqi Hu, Kaiping Zhou, Shijin Li, Zhanjie Feng, Francesco Pilla   +6 more
doaj   +1 more source

Parallel Dynamic Spatial Indexes

Proceedings of the 31st ACM SIGPLAN Annual Symposium on Principles and Practice of Parallel Programming
Maintaining spatial data (points in two or three dimensions) is crucial and has a wide range of applications, such as graphics, GIS, and robotics. To handle spatial data, many data structures, called spatial indexes, have been proposed, e.g. kd-trees, oct/quadtrees (also called Orth-trees), R-trees, and bounding volume hierarchies (BVHs). In real-world
Ziyang Men, Bo Huang, Yan Gu 0001, Yihan Sun 0001   +3 more
openaire   +2 more sources