Results 81 to 90 of about 429,151 (266)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
INNOVATION ACCELERATORS AS ENTREPRENEURIAL AND INTERDISCIPLINARY ENGINES: THE PORTUGUESE CASE [PDF]
Journal of Spatial and Organizational Dynamics, 2016 Today’s competition is tough, due especially to emergent information systems (IS) and information technology (IT) support. Managers must continuously cope with challenges to keep their businesses innovative and sustainable.
Silvia Fernandes
doaj
Spatial and temporal dynamics of the endothelium [PDF]
Journal of Thrombosis and Haemostasis, 2005 The endothelium is a highly metabolically active organ that is involved in many physiological processes, including the control of vasomotor tone, barrier function, leukocyte adhesion and trafficking, inflammation, and hemostasis. Endothelial cell phenotypes are differentially regulated in space and time.
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Spatial Dynamics and Urban Models [PDF]
, 1989 Analogies and model transfer from one branch of research to another are often fruitful. They encourage new development in knowledge by using already elaborated formalisms or models and by suggesting new questions which may lead to new fields of research.
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Modern Board Games: Can They Be Geogames?
Urban PlanningThis article addresses the evolving concept of geogames, traditionally focused on digital and location‐based experiences, and explores the potential of modern board games as an analogue form of geogame.
Micael Sousa +4 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Dynamic spatial regimes for spatial panel data
Spatial StatisticsSpatial heterogeneity in terms of spatially-varying coefficients is often not properly considered in modeling economic data. This neglect might cause serious problems in the estimation of the parameters of a model specification when group-wise heterogeneity is at work.
Anna Gloria Billé +2 more
openaire +3 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source