Results 71 to 80 of about 429,151 (266)

Diagnosing Pandemic Disaster Risk Management through Impact Chains and Forensic Analysis: An Intertwined DRM Model and Key Lessons from the Hospital Network in Bucharest, Romania

International Journal of Disaster Risk Science
The COVID-19 pandemic has tested the limits of healthcare facilities around the world, disrupting the provision of essential preventive and curative services.
Andra-Cosmina Albulescu, Iuliana Armaș, Funda Atun, Cristina Savu   +3 more
doaj   +1 more source

Progression of the smoking epidemic in high-income regions and its effects on male-female survival differences: a cohort-by-age analysis of 17 countries

BMC Public Health, 2020
Background Of all lifestyle behaviours, smoking caused the most deaths in the last century. Because of the time lag between the act of smoking and dying from smoking, and because males generally take up smoking before females do, male and female smoking ...
Maarten Wensink, Jesús-Adrián Alvarez, Silvia Rizzi, Fanny Janssen, Rune Lindahl-Jacobsen   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Entrepreneurship Education: Economic Analys is of an Entrepreneurial Training Program based on Pupil Enterprises in Portugal [PDF]

Journal of Spatial and Organizational Dynamics, 2016
Promoting creativity and entrepreneurship has been identified as being essential for the development of countries; therefore, it is crucial to implement entrepreneurship educational training projects. Based on this assumption, the Entrepreneurship in the
Susana Imaginário, Eurídice Cristo, Saul Neves de Jesus, Fátima Morais   +3 more
doaj  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Peatland development reconstruction and complex biological responses to permafrost thawing in Western Siberia [PDF]

Biogeosciences
Western Siberian peatlands are among the largest peatland complexes in the world and play a crucial role in regulating the global climate. However, a lack of long-term, multi-proxy studies comprehensively examining the interactions between permafrost ...
A. Halaś, M. Lamentowicz, M. Obremska, D. Łuców, M. Słowiński   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An impact-chain-based exploration of multi-hazard vulnerability dynamics: the multi-hazard of floods and the COVID-19 pandemic in Romania [PDF]

Natural Hazards and Earth System Sciences
In light of the increased frequency of multi-hazards, the dynamics of vulnerability across time, space, and different hazards emerges as an intriguing but challenging research topic.
A.-C. Albulescu, A.-C. Albulescu, I. Armaș   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source