Results 91 to 100 of about 1,974,870 (293)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

The Binocular Balance at High Spatial Frequencies as Revealed by the Binocular Orientation Combination Task

open access: yesFrontiers in Human Neuroscience, 2019
How to precisely quantify the binocular eye balance (i.e., the contribution that each eye makes to the binocular percept) across a range of spatial frequencies using a binocular combination task, is an important issue in both clinical and basic research.
Yonghua Wang   +24 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Radiographic applications of spatial frequency multiplexing [PDF]

open access: yes
The application of spacial frequency encoding techniques which allow different regions of the X-ray spectrum to be encoded on conventional radiographs was studied. Clinical considerations were reviewed, as were experimental studies involving the encoding
Macovski, A.
core   +1 more source

On the Influence of Spatial Dispersion on the Performance of Graphene-Based Plasmonic Devices

open access: yes, 2014
We investigate the effect of spatial dispersion phenomenon on the performance of graphene-based plasmonic devices at THz. For this purpose, two different components, namely a phase shifter and a low-pass filter, are taken from the literature, implemented
Alvarez-Melcon, Alejandro   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Editorial: The Contrast Sensitivity Function: From Laboratory to Clinic

open access: yesFrontiers in Neuroscience, 2021
Fang Hou   +5 more
doaj   +1 more source

The effect of tinted spectacle lenses on contrast sensitivity and colour vision

open access: yesAfrican Vision and Eye Health, 2013
Aim: Spectacle wearers often prefer tintedlenses to clear or non-tinted lenses for their protection against harmful radiation, improved cos- mesis, enhancement of visual performance and effects on colour vision.
M. Shaik   +6 more
doaj   +1 more source

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