Results 81 to 90 of about 13,582,146 (349)
Geostatistical-based index for spatial variability in soil properties [PDF]
Revista Brasileira de Ciência do SoloThe assessment of spatial variability of environmental variables such as soil properties is important for site-specific management. A geostatistical index that allows quantifying and characterizing the structure of spatial variability is fundamental in ...
Edemar Appel Neto +2 more
doaj +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Monitoring index drawing out for dam spatial deformation
Shuili Shuiyun Gongcheng Xuebao, 2016 Regarding the lack of consideration about spatiality and fuzziness in the traditional methods in drawing out the dam safety monitoring index,this paper decreases dimensions of displacement sequence at different heights in a dam by projection pursuit (PP)
SUN Peng-ming +4 more
doaj +1 more source
Towards a Painless Index for Spatial Objects [PDF]
ACM Transactions on Database Systems, 2014 Conventional spatial indexes, represented by the R-tree, employ multidimensional tree structures that are complicated and require enormous efforts to implement in a full-fledged database management system (DBMS). An alternative approach for supporting spatial queries is mapping-based indexing, which maps both data and queries into a one ...
Rui Zhang 0003 +3 more
openaire +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
The Spatial Dimension of Human Development Index in Indonesia [PDF]
As the new paradigm of economic development pioneered by UNDP and Mahbub Ul-Haq undertaken, development processes no longer viewed as monodimensional process of economic growth indicated by GDP growth solely.
Rullan Rinaldi, Eva Nurwita
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
A spatial vulnerability index for environmental health
Ecological IndicatorsExtreme natural hazards are increasing in frequency and intensity. These natural changes in our environment, combined with man-made pollution, have substantial economic, social and health impacts globally.
Aiden Price +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source