Results 71 to 80 of about 13,582,146 (349)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Spatial Relationship between Land Use Patterns and Ecosystem Services Value—Case Study of Nanjing
Land, 2022 The degree of land use reflects the progress of social and economic development; however, it also has a direct impact on land resources. Maximizing the ecosystem services of land resources in a limited space is a key issue in China’s rapid urbanization ...
Ming Lu +3 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Index structures for flexible querying in fuzzy spatial databases
, 2004 Database systems can be effective only if the data are properly handled at the physical level. Therefore, it is important to develop an effective spatial and aspatial indexing technique to facilitate flexible spatial and/or aspatial querying for spatial ...
Yazıcı, Adnan, Yazici, A, Sozer, A
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Integrating NoSQL, Hilbert Curve, and R*-Tree to Efficiently Manage Mobile LiDAR Point Cloud Data
ISPRS International Journal of Geo-InformationThe widespread use of Light Detection and Ranging (LiDAR) technology has led to a surge in three-dimensional point cloud data; although, it also poses challenges in terms of data storage and indexing.
Yuqi Yang +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Jurnal Pembangunan Wilayah dan Kota, 2020 Jabodetabek and Greater Bandung Metropolitan areas experiencing the phenomenon of urban expansion which has caused both metropolitan areas to be more connected and become a mega-urban area by a corridor through a conurbation process.
Alfin Murtadho +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Spatial clustering method for geographic data [PDF]
, 2002 In the process of visualizing quantitative spatial data, it is necessary to classify attribute values into some class divisions. In a previous paper, the author proposed a classification method for minimizing the loss of information contained in ...
Osaragi, Toshihiro
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