Results 51 to 60 of about 534 (212)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Towards a Painless Index for Spatial Objects [PDF]
ACM Transactions on Database Systems, 2014 Conventional spatial indexes, represented by the R-tree, employ multidimensional tree structures that are complicated and require enormous efforts to implement in a full-fledged database management system (DBMS). An alternative approach for supporting spatial queries is mapping-based indexing, which maps both data and queries into a one ...
Rui Zhang 0003 +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
HPG-Tree: An Enhanced
IEEE AccessIn modern applications such as geographic information systems, game development, and image processing, the demand for efficient two-dimensional spatial indexing is rising exponentially. Traditional approaches like R-tree can suffer from excessive overlap
Amal Saif +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Applied SciencesMultiscale 3D geological characterization and joint analysis are increasingly important topics in spatial information science. However, the non-uniform spatial distribution of objects and scale heterogeneity in geological surveys lead to dispersed ...
Genshen Chen +6 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Jixie chuandong, 2012 By the spatial coordinate transformation theory and conjugate theory the mathematic model of cylindrical indexing cam mechanism is established,and then by the 3D modeling software Pro/E,its 3D solid model is built,and the simulation of cylindrical ...
王晓辉, 廉哲满
doaj
RL-RTree: A Reinforcement Learning-Optimized Dynamic R-Tree for High-Dimensional Spatial Indexing
IEEE AccessSpatial indexing in high-dimensional dynamic environments faces critical challenges, including the curse of dimensionality and rapid distribution shifts, which degrade the performance of traditional indexes like R*-trees and static learned indexes.
Yongxin Peng
doaj +1 more source
PostGIS-powered proximity queries: implementation and Google Maps visualization [PDF]
PeerJ Computer ScienceLocation-based services require efficient methods to calculate nearby points of interest. This article presents an implementation methodology for proximity queries using PostgreSQL’s PostGIS extension, focusing on the ST_DWithin function and spatial ...
Pavan Kumar Papasani, Ravi Teja Papasani
doaj +2 more sources