Results 61 to 70 of about 2,238,587 (282)

Children’s and young people’s cognizance of physical-symbolic reality: The production and acquisition of spatial knowledge

open access: yes[i2]: Investigación e Innovación en Arquitectura y Territorio
In this article, we address the central topic of the call for papers, childhood educates space, from the perspective of children’s and young people’s spatial knowledge. We argue that both childhood and youth educate as much as are educated by space.
Ignacio Castillo Ulloa   +3 more
doaj   +1 more source

An Exploratory Study Investigating Gender Effects on Using 3D Maps for Spatial Orientation in Wayfinding

open access: yesISPRS International Journal of Geo-Information, 2017
3D representations in applications that provide self-localization and orientation in wayfinding have become increasingly popular in recent years because of technical advances in the field.
Hua Liao, Weihua Dong
doaj   +1 more source

The Effects of Finger-Walking in Place (FWIP) on Spatial Knowledge Acquisition in Virtual Environments [PDF]

open access: yes, 2009
Spatial knowledge, necessary for efficient navigation, comprises route knowledge (memory of landmarks along a route) and survey knowledge (overall representation like a map).
Gracanin, Denis   +2 more
core   +1 more source

The arable farmer as the assessor of within-field soil variation [PDF]

open access: yes, 2010
Feasible, fast and reliable methods of mapping within-field variation are required for precision agriculture. Within precision agriculture research much emphasis has been put on technology, whereas the knowledge that farmers have and ways to explore it ...
Bregt, A.K., Bruin, S., de, Heijting, S.
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

A Connectionist Model of Spatial Knowledge Acquisition in a Virtual Environment [PDF]

open access: yes, 2003
This paper proposes the use of neural networks as a tool for studying navigation within virtual worlds. Results indicate that network learned to predict the next step for a given trajectory, acquiring also basic spatial knowledge in terms of landmarks ...
O'Hare, G.M.P., Reilly, R., Sas, Corina
core  

A network-based view of regional growth [PDF]

open access: yes, 2013
The need to better understand the mechanisms underlying regional growth patterns is widely recognised. This paper argues that regional growth is partly a function of the value created through inter-organisational flows of knowledge within and across ...
Huggins, R, Thompson, P
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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