Results 61 to 70 of about 21,167 (259)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Holographic Fabrication of Designed Functional Defect Lines in Photonic Crystal Lattice Using a Spatial Light Modulator

Micromachines, 2016
We report the holographic fabrication of designed defect lines in photonic crystal lattices through phase engineering using a spatial light modulator (SLM). The diffracted beams from the SLM not only carry the defect’s content but also the defect related
Jeffrey Lutkenhaus, David Lowell, David George, Hualiang Zhang, Yuankun Lin   +4 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Experimental Study of Reconfigurable Visible Light Communications Based on Holographic Spot Array Generations

IEEE Photonics Journal, 2018
An experimental study of a reconfigurable visible light communication (VLC) system, using liquid crystal on silicon-based spatial light modulator, which dynamically offers multicast transmission, for indoor optical wireless communication configuration is
Hsi-Hsir Chou, Cheng-Yu Tsai, Chia-Lun Chen   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

In situ single-atom array synthesis using dynamic holographic optical tweezers

Nature Communications, 2016
It would be desirable to have a reliable and scalable method to manipulate neutral-atoms for the creation of controllable quantum systems. Here the authors demonstrate real-time transport of single rubidium atoms in holographic microtraps controlled by ...
Hyosub Kim, Woojun Lee, Han-gyeol Lee, Hanlae Jo, Yunheung Song, Jaewook Ahn   +5 more
doaj   +1 more source

Multi-spectral random illumination using a liquid crystal spatial light modulator

Journal of the European Optical Society-Rapid Publications, 2018
Background Using phase-only liquid crystal spatial light modulator (LC-SLM) to generate random illumination is always used in phase-retrieval and single pixel imaging as it have high energy efficiency.
Xiao Chen, Zhiguang Shi, Weidong Hu
doaj   +1 more source

Scalable micromesh-digital spatial light modulators

Optics Express, 2015
Digital spatial light modulators (SLMs) with small pitch comparable to the wavelength of illuminating light and large physical dimension comparable to consumer displays are highly demanding for realizing realistic digital holography but are impractical due to various technical issues. Previously we proposed the way to overcome these hurdles by scalable
Hoon, Jeong, Jaewu, Choi
openaire   +2 more sources