Results 41 to 50 of about 286,986 (263)
Frontiers in Systems Neuroscience, 2017 The subiculum and the lateral entorhinal cortex (LEC) are the main output areas of the hippocampus which contribute to spatial and non-spatial memory.
Shih-pi Ku +12 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Sports training enhances visuo-spatial cognition regardless of open-closed typology [PDF]
PeerJ, 2017 The aim of this study was to investigate the effects of open and closed sport participation on visuo-spatial attention and memory performance among young adults.
Ting-Yu Chueh +5 more
doaj +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Testing Conclusions From Functional Imaging of Working Memory with Data From Acute Stroke
Behavioural Neurology, 2007 Functional imaging studies indicate that the left hemisphere mediates verbal working memory, while the right hemisphere mediates both verbal and spatial working memory.
Lisa E. Philipose +3 more
doaj +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Spatial Organization in Self-Initiated Visual Working Memory
Frontiers in Psychology, 2019 Ample research in visual working memory (VWM) has demonstrated that the memorized items are maintained in integrated spatial configurations, even when the spatial context is task irrelevant.
Hagit Magen, Tatiana Aloi Emmanouil
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The lateralization of left hippocampal CA3 during the retrieval of spatial working memory
Nature Communications, 2020 The CA3 region of the hippocampus is involved in spatial working memory. Here, the authors show that neurons in the left CA3 are more active in the choice phase of correct trials of spatial working memory than neurons in the right CA3, revealing ...
Da Song +19 more
doaj +1 more source
Cognitive impairment in a sample of adult patients with multiple sclerosis: an Egyptian study
Middle East Current Psychiatry, 2023 Background Multiple sclerosis is a chronic neuro-inflammatory disease of the brain and central nervous system. We aimed at assessing the cognitive functions present in adult patients with multiple sclerosis in remission phase of the disease comparing ...
Sara Elbasuony Elshehawy +3 more
doaj +1 more source