Results 121 to 130 of about 27,601,135 (361)

arf3DS4: An Integrated Framework for Localization and Connectivity Analysis of fMRI Data

Journal of Statistical Software, 2011
In standard fMRI analysis all voxels are tested in a massive univariate approach, that is, each voxel is tested independently. This requires stringent corrections for multiple comparisons to control the number of false positive tests (i.e., marking ...
Hilde M. Huizenga, Wouter D. Weeda, Raoul Grasman, Lourens J. Waldorp, Frank de Vos   +4 more
doaj  

The impact of spatial scales and spatial smoothing on the outcome of bayesian spatial model.

, 2013
Discretization of a geographical region is quite common in spatial analysis. There have been few studies into the impact of different geographical scales on the outcome of spatial models for different spatial patterns.
James McGree, Kerrie Mengersen, Mengersen, Kerrie, Su Yun Kang, McGree, James, Kang, Su Yun   +5 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

MODEL KERUANGAN UNTUK IDENTIFIKASI KAWASAN RAWAN LONGSOR

Tataloka, 2016
This study aims to develop a spatial model based on Geographic Information System (GIS) that can be used to identify landslide prone areas. The model uses map overlay and tabular weighted methods involving seven variables, i.e.
Imam Buchori, Joko Susilo
doaj   +1 more source

Learning Spatial Models for Navigation [PDF]

, 2015
Typically, autonomous robot navigation relies on a detailed, accurate map. The associated representations, however, do not readily support human-friendly interaction. The approach reported here offers an alternative: navigation with a spatial model and commonsense qualitative spatial reasoning. Both are based on research about how people experience and
Susan L. Epstein, Anoop Aroor, Matthew Evanusa, Elizabeth I. Sklar, Simon Parsons   +4 more
openaire   +2 more sources

Spatial analysis of the error in a model of soil nitrogen

, 2008
Models of the dynamics of nitrogen in soil (soil-N) can be used to aid the fertilizer management of a crop. The predictions of soil-N models can be validated by comparison with observed data.
Baxter, S. J., Lark, R. M., Pringle, M. J., Marchant, B. P.   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source