Results 81 to 90 of about 601,910 (308)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Visibility-Based Demodulation of Rhessi Light Curves

open access: yes, 2004
The Reuven Ramaty High Energy Spectroscopic Solar Imager (RHESSI) uses the rotational modulation principle to observe temporally, spatially, and spectrally resolved hard X ray and gamma ray images of solar flares. In order to track the flare evolution on
Arzner   +7 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Fully signed quadrature space shift keying MIMO modulation

open access: yesAin Shams Engineering Journal
A novel multiple-input multiple-output (MIMO) space shift keying (SSK) modulation scheme, termed fully signed quadrature space shift keying (FSQ-SSK), is proposed in this paper.
Hany S. Hussein   +4 more
doaj   +1 more source

Multi-Set Space-Time Shift Keying and Space- Frequency Space-Time Shift Keying for Millimeter-Wave Communications

open access: yesIEEE Access, 2017
In this paper, we introduce a novel OFDM-aided multifunctional multiple-input multiple-output scheme based on multi-set space-time shift keying (MS-STSK), where the information transmitted over each subcarrier is divided into two parts: STSK codeword and
Ibrahim A. Hemadeh   +3 more
doaj   +1 more source

The Consequences of the modulation instabilities [PDF]

open access: yes, 2018
There are various cases of the development of the modulation instability of intense periodic structures in wave and non-wave media (see, for example [1]). The peculiarity of the modulation instability is the appearance of the perturbation spectrum, which
Kuklin, V.M., Куклин, В.М.
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

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