Results 81 to 90 of about 604,964 (331)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Realization and MIMO-link measurements of a transmit module for spatial modulation [PDF]

, 2015
This paper describes the realization of a circuit that transmits a data stream, through spatial modulation in the 2.45 GHz frequency band. The development of the transmitter includes RF circuit design with components such as a PLL synthesizer, Tx-DAC and
Van Torre, Patrick, Verhaevert, Jo
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Fully signed quadrature space shift keying MIMO modulation

Ain Shams Engineering Journal
A novel multiple-input multiple-output (MIMO) space shift keying (SSK) modulation scheme, termed fully signed quadrature space shift keying (FSQ-SSK), is proposed in this paper.
Hany S. Hussein, Abdulrahman Al Ayidh, Ehab Mahmoud Mohamed, Hamada Esmaiel, Mohammed Farrag   +4 more
doaj   +1 more source

The Consequences of the modulation instabilities [PDF]

, 2018
There are various cases of the development of the modulation instability of intense periodic structures in wave and non-wave media (see, for example [1]). The peculiarity of the modulation instability is the appearance of the perturbation spectrum, which
Kuklin, V.M., Куклин, В.М.
core  

Visibility-Based Demodulation of Rhessi Light Curves

, 2004
The Reuven Ramaty High Energy Spectroscopic Solar Imager (RHESSI) uses the rotational modulation principle to observe temporally, spatially, and spectrally resolved hard X ray and gamma ray images of solar flares. In order to track the flare evolution on
Arzner, Fivian, Hurford, Hurford, K Arzner, Lin, Miller, Smith   +7 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

APPLICATIONS OF THE LIGHT LASER WITH SPATIAL INCOHERENCE AND BIONIC OPTIMIZATION TO THE OPTICAL WIRELESS COMMUNICATIONS

Revista de Investigaciones Universidad del Quindío, 2014
The bioelectronics takes of the biology the optimized elements for to do a copy and to build technological mechanisms with functions based in that of body lives components.
Samuel Ángel Jaramillo Flórez, Yuli Fernanda Achipiz   +1 more
doaj   +1 more source