Results 71 to 80 of about 292,599 (242)

The Impact Of Location On The Role Of Small Towns In Regional Development: Mazovia, Poland

European Countryside, 2016
The paper explores the role of small towns in the Mazovia region in Poland which is both characterized by rural areas and the suburban zone of Warsaw.
Czapiewski Konrad, Bański Jerzy, Górczyńska Magdalena   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The role of microclimate in supporting peatlands as climate‐change refugia: A Central European perspective

Conservation Science and Practice
Central European peatlands are important biodiversity hotspots and potential climate‐change refugia, preserving post‐glacial relict species and offering insights into long‐term ecological functioning.
Sandra Słowińska, Michał Ronikier, Wojciech Paul, Adrian Kaszkiel, Patrycja Kowalczyk, Michał Słowiński   +5 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Climatic Determinants of Changes in the Ice Regime of Carpathian Rivers

Quaestiones Geographicae
The study addresses the influence of climatic conditions on changes in the ice regime of Carpathian rivers (Central Europe) over the period 1980–2020.
Fukś Maksymilian, Wiejaczka Łukasz
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Invasive neophytes alter ecological functions and services of riparian hardwood forests

Ecological Indicators
Riparian hardwood forests, now rare in Europe, occur in small patches within agricultural landscapes and are important biodiversity hotspots protected by the EU Habitats Directive and monitored.
Anna Kowalska, Ewa Kołaczkowska
doaj   +1 more source

Human impact in the Tatra Mountains

Cuadernos de Investigación Geográfica, 2019
Human activity is one of the three main drivers of environmental changes in the mountains. Its influence on mountain natural environment is characterized by great spatiotemporal diversity. In the Tatras human impact started in the 12th-13th centuries and
Z. Rączkowska
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Historical charcoal production as a factor in soil cover heterogeneity in a fluvioglacial landscape − A case study from northern Poland

Geoderma
Although in situ wood thermal processing, as a common practice in European forests in historical times, has been confirmed in many studies, the environmental implications of that process remain poorly explored. In this study, we focused on evaluating the
Jerzy Jonczak, Vincenzo Barbarino, Aleksandra Chojnacka, Bogusława Kruczkowska, Krzysztof Szewczyk, Barbara Gmińska-Nowak, Ewa Kołaczkowska, Dominika Łuców, Agnieszka Halaś, Agnieszka Mroczkowska, Sandra Słowińska, Mateusz Kramkowski, Anna Kowalska, Michał Słowiński   +13 more
doaj   +1 more source