Results 91 to 100 of about 364,113 (314)

Self-Organization and Vegetation Collapse in Salt Marsh Ecosystems [PDF]

, 2005
Complexity theory predicts that local feedback processes may strongly affect the organization of ecosystems on larger spatial scales. Whether complexity leads to increased resilience and stability or to increased vulnerability and criticality remains one
Bakker, J P, Herman, PMJ, Herman, P.M.J., Van de Koppel, J., Bakker, J.P., van de Koppel, J, Bakker, JP, Van der Wal, D., van der Wal, D, Herman, P M J   +9 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Bayesian Inference of Spatial Organizations of Chromosomes

PLoS Computational Biology, 2013
Knowledge of spatial chromosomal organizations is critical for the study of transcriptional regulation and other nuclear processes in the cell. Recently, chromosome conformation capture (3C) based technologies, such as Hi-C and TCC, have been developed to provide a genome-wide, three-dimensional (3D) view of chromatin organization.
Ming Hu 0001, Ke Deng, Zhaohui S. Qin, Jesse R. Dixon, Siddarth Selvaraj, Jennifer Fang, Bing Ren, Jun S. Liu   +7 more
openaire   +6 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

The Character of Knowledge Transfer Resulting from Interactions between the Rural Oldtimers and Rural Newcomers

European Countryside
The research objective of the paper is to diagnose and assess knowledge transfer, taking place within rural areas as a consequence of contacts between rural inhabitants and the newcomers from towns.
Bański Jerzy, Bednarek-Szczepańska Maria   +1 more
doaj   +1 more source

Neighbouring the different: Social interaction in a Warsaw subarea

Bulletin of Geography. Socio-Economic Series, 2018
In the paper patterns of social interaction are examined, as shaped by an inflow of new residents to an inner-city subarea characterized by a low socio-economic status and featuring ethnic homogeneity. The empirical material is derived from a set of semi-
Korcelli-Olejniczak Ewa, Piotrowski Filip   +1 more
doaj   +1 more source

Peat core research in the Western Siberian Lowland: applications of palaeoecological proxies, regions studied, and future prospects [PDF]

Earth System Science Data
Peatlands are natural archives that preserve information not only about their own development but also about past environmental conditions in surrounding landscapes.
A. Halaś, M. Słowiński
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

General elections in Poland (1990–2024) in the unified territorial aggregation: GeoElections Poland 1.0

Scientific Data
We share dataset of all general elections held in Poland between 1990 and 2024. These datasets correspond to two degrees of spatial aggregation: 41 constituencies for the Sejm and 94 for the Senate. In this dataset, for the first time, it was possible to
Przemysław Śleszyński, Mariusz Kowalski   +1 more
doaj   +1 more source